Custom Enzymes and Inhibitors

R&D Systems proTAME

Cell-permeable APC/C inhibitor

R&D Systems NEDD8 E1 Activating Enzyme Inhibitor

Contains the active component of MLN4924, a cell-permeable, small molecule inhibitor of Nedd8 activating enzyme

BD FUT-175 (Futhan) Available on GSA/VA Contract for Federal Government customers only.

Synthetic, broad-specificity protease inhibitor and an inhibitor of the classical and alternate pathways of complement activation

R&D Systems Epoxomicin

Cell-permeable, potent, selective and irreversible proteasome inhibitor

R&D Systems clasto-Lactacystin beta Lactone

Potent, highly specific, irreversible and cell-permeable inhibitor that covalently modifies the beta subunits of the proteasome

R&D Systems Caspase Inhibitor Control Z-FA-FMK

Designed for in vitro use as a cell permeable control for the effects of fluoromethyl-ketone derivatives on caspase activity

R&D Systems Z-Leu-Leu-Nva-CHO (MG-115)

Reversible, cell-permeable chymotrypsin-like peptidase inhibitor of the 20S proteasome

BD General Caspase Inhibitor, Z-VAD-FMK Available on GSA/VA Contract for Federal Government customers only.

Cell permeable general caspase inhibitor that binds to the catalytic site of caspase proteases irreversibly and inhibits apoptosis

R&D Systems PS-341, 26S Proteasome Inhibitor

A potent, specific, and reversible proteasome inhibitor

Thermo Scientific™ EpiJET™ Bisulfite Conversion Kit

The EpiJET Bisulfite Conversion Kit is used for an efficient bisulfite modification of DNA for methylation analysis.

BD Caspase-3 Inhibitor, Z-DEVD-FMK Available on GSA/VA Contract for Federal Government customers only.

Irreversible and cell permeable inhibitor of caspase-3

R&D Systems Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Highly potent and selective cell-permeable inhibitor of the proteasome

BostonBiochem UbiCREST Enzyme Set

Polyubiquitin chain linkage analysis system

R&D Systems b-AP15/VLX1500

Specifically inhibits the 19S regulatory particle-associated deubiquitinases USP14 and UCHL5, resulting in the accumulation of intracellular polyubiquitin

BD Ac-IETD-CHO Caspase-8 Inhibitor Available on GSA/VA Contract for Federal Government customers only.

To study caspase-8 activity in apoptotic cell lysates

BD Caspase-9 Inhibitor, Z-LEHD-FMK Available on GSA/VA Contract for Federal Government customers only.

Irreversible and cell permeable inhibitor of caspase-9

BD Ac-DEVD-CHO Inhibitor Available on GSA/VA Contract for Federal Government customers only.

To identify and quantify Caspase-3 activity in apoptotic cells, and to study events downstream of Caspase-3 activation

R&D Systems Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Reversible, cell-permeable chymotrypsin-like peptidase inhibitor of the 20S proteasome

BD Caspase-8 Inhibitor, Z-IETD-FMKK Available on GSA/VA Contract for Federal Government customers only.

Irreversible and cell permeable inhibitor of caspase-8

R&D Systems Me4BodipyFL-Ahx3Leu3VS (Proteasome Activity Probe)

A cell-permeable fluorescent proteasome activity probe for accurate profiling of proteasomal activity in cell lysates, intact cells, and murine and human patient-derived material, with high sensitivity

BD Negative Control for Caspase Inhibitors, Z-FA-FMK Available on GSA/VA Contract for Federal Government customers only.

A negative control inhibitor which has no inhibitory effect on apoptosis mediated by caspases and can only inhibit cysteine proteases

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