Custom Enzymes and Inhibitors

Thermo Scientific™ EpiJET™ Bisulfite Conversion Kit

The EpiJET Bisulfite Conversion Kit is used for an efficient bisulfite modification of DNA for methylation analysis.

BostonBiochem UbiCREST Enzyme Set

Polyubiquitin chain linkage analysis system

BD Ac-DEVD-CHO Inhibitor Available on GSA/VA Contract for Federal Government customers only.

To identify and quantify Caspase-3 activity in apoptotic cells, and to study events downstream of Caspase-3 activation

R&D Systems proTAME

Cell-permeable APC/C inhibitor

R&D Systems NEDD8 E1 Activating Enzyme Inhibitor

Contains the active component of MLN4924, a cell-permeable, small molecule inhibitor of Nedd8 activating enzyme

R&D Systems Epoxomicin

Cell-permeable, potent, selective and irreversible proteasome inhibitor

BD General Caspase Inhibitor, Z-VAD-FMK Available on GSA/VA Contract for Federal Government customers only.

Cell permeable general caspase inhibitor that binds to the catalytic site of caspase proteases irreversibly and inhibits apoptosis

R&D Systems Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Reversible, cell-permeable chymotrypsin-like peptidase inhibitor of the 20S proteasome

BD FUT-175 (Futhan) Available on GSA/VA Contract for Federal Government customers only.

Synthetic, broad-specificity protease inhibitor and an inhibitor of the classical and alternate pathways of complement activation

BD Negative Control for Caspase Inhibitors, Z-FA-FMK Available on GSA/VA Contract for Federal Government customers only.

A negative control inhibitor which has no inhibitory effect on apoptosis mediated by caspases and can only inhibit cysteine proteases

BD Ac-IETD-CHO Caspase-8 Inhibitor Available on GSA/VA Contract for Federal Government customers only.

To study caspase-8 activity in apoptotic cell lysates

R&D Systems Z-Leu-Leu-Nva-CHO (MG-115)

Reversible, cell-permeable chymotrypsin-like peptidase inhibitor of the 20S proteasome

BD Caspase-3 Inhibitor, Z-DEVD-FMK Available on GSA/VA Contract for Federal Government customers only.

Irreversible and cell permeable inhibitor of caspase-3

R&D Systems Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Highly potent and selective cell-permeable inhibitor of the proteasome

R&D Systems b-AP15/VLX1500

Specifically inhibits the 19S regulatory particle-associated deubiquitinases USP14 and UCHL5, resulting in the accumulation of intracellular polyubiquitin

R&D Systems clasto-Lactacystin beta Lactone

Potent, highly specific, irreversible and cell-permeable inhibitor that covalently modifies the beta subunits of the proteasome

BD Caspase-9 Inhibitor, Z-LEHD-FMK Available on GSA/VA Contract for Federal Government customers only.

Irreversible and cell permeable inhibitor of caspase-9

R&D Systems Me4BodipyFL-Ahx3Leu3VS (Proteasome Activity Probe)

A cell-permeable fluorescent proteasome activity probe for accurate profiling of proteasomal activity in cell lysates, intact cells, and murine and human patient-derived material, with high sensitivity

BD Caspase-8 Inhibitor, Z-IETD-FMKK Available on GSA/VA Contract for Federal Government customers only.

Irreversible and cell permeable inhibitor of caspase-8

R&D Systems PS-341, 26S Proteasome Inhibitor

A potent, specific, and reversible proteasome inhibitor

R&D Systems Caspase Inhibitor Control Z-FA-FMK

Designed for in vitro use as a cell permeable control for the effects of fluoromethyl-ketone derivatives on caspase activity

R&D Systems ATPγS Tetralithium Salt

Functions as a ligand-gated ion channel. R&D Systems ATPγS tetralithium salt is P2 purinergic receptor agonist, Nonhydrolyzable analog of ATP.

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