Crosslinking Reagents

Thermo Scientific™ Pierce™ PEG4-SPDP Crosslinker

Long (25.7A) amine-to-sulfhydryl crosslinker; NHS-ester and pyridyldithiol groups at ends of 4-unit polyethylene glycol spacer arm; forms cleavable disulfide bonds; water-soluble.

Thermo Scientific™ Pierce™ SIA Crosslinker

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 3-atom (1.5A) spacer arm.

Thermo Scientific™ Pierce™ NHS-Diazirine Crosslinkers

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

Thermo Scientific™ Pierce™ Premium Grade SPDP

Crosslink proteins and other biomolecules in applications where product integrity and risk minimization are paramount with Thermo Scientific™ Pierce™ Premium Grade SPDP, a high-quality formulation of this popular pyridyldithiol-based amine-to-sulfhydryl crosslinker.

Thermo Scientific™ Pierce™ PEG12-SPDP Crosslinker

Very long (54.1A) amine-to-sulfhydryl crosslinker; NHS-ester and pyridyldithiol groups at ends of 12-unit polyethylene glycol spacer arm; forms cleavable disulfide bonds; water-soluble.

Thermo Scientific™ Pierce™ SMCC Crosslinker

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of a stabilizing cyclohexane-containing, 8-atom spacer arm.

Thermo Scientific™ Pierce™ NHS-Azide Staudinger Ligation Reagents

Activated azido compounds to derivatize proteins or amine surfaces for selective conjugation, detection or purification by phosphine-modified probes.

Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Thermo Scientific™ Pierce™ DMP Crosslinker

Crosslink amines to amines with dimethyl pimelimidate (CAS 58537-94-3); composed of imidoester groups and a membrane-permeable, 7-atom spacer arm.

Thermo Scientific™ Pierce™ SM(PEG)n Crosslinkers

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Thermo Scientific™ Pierce™ LC-SMCC Crosslinker

Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of a stabilizing cyclohexane-containing, 15-atom spacer arm.

Thermo Scientific™ Pierce™ Sulfo-KMUS Crosslinker

Crosslink amines to sulfhydryls with this long crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aliphatic, 13-atom (16.3A) spacer arm.

Thermo Scientific™ Pierce™ TMEA Crosslinker

A 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine; composed of three maleimide groups on short spacer arms; conjugate protein or peptide cysteines.

Thermo Scientific™ Pierce™ NHS-Phosphine Staudinger Ligation Reagents

Derivatize proteins or amine surfaces for selective conjugation, detection or purification of azide-tagged targets with these activated phosphine compounds.

Thermo Scientific™ Pierce™ Controlled Protein-Protein Crosslinking Kit

Chemically conjugate any two purified proteins (antibodies, enzymes, carriers, etc.) using sulfo-SMCC crosslinker, a complete kit with modification reagents and buffers.

Thermo Scientific™ Pierce™ DSP Crosslinker

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

Thermo Scientific™ Pierce™ Sulfo-EGS Crosslinker

Crosslink amines to amines with a crosslinker composed of sulfo-NHS-ester groups and hydroxylamine-cleavable spacer arm; water-soluble for cell-surface protein crosslinking.

Thermo Scientific™ Pierce™ SMPH Crosslinker

Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 12-atom (14.2A) spacer arm.

Thermo Scientific™ Pierce™ DMA Crosslinker

Crosslink amines to amines with dimethyl adipimidate (CAS 14620-72-5); composed of imidoester groups and a 6-atom, membrane-permeable spacer arm.

Thermo Scientific™ Pierce™ Sulfo-SIAB Crosslinker

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker composed of sulfo-NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 9-atom spacer arm.

Thermo Scientific Pierce™ Premium Grade Sulfo-NHS

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this N-hydroxysuccinimide modification reagent.

Thermo Scientific™ Pierce™ KMUH Crosslinker

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this long (19.0A) crosslinker containing maleimide and hydrazide groups.

Thermo Scientific Pierce™ Premium Grade Sulfo-SMCC

Optimize applications where product integrity and risk minimization are paramount our highest quality formulation of this popular amine-to-sulfhydryl crosslinker.

Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Thermo Scientific™ Pierce™ TSAT Crosslinker

A 3-way, short-arm (4.2A) amine-to-amine crosslinker; tris (succinimidyl) aminotriacetate, composed of three NHS-ester groups on short spacer arms; membrane permeable.

Thermo Scientific™ Pierce™ Photoreactive Amino Acids

Diazirine analogs of leucine and methionine to express proteins in cell culture that will crosslink their protein interactors upon UV-light activation in vivo.

Thermo Scientific™ Pierce™ EMCH Crosslinker

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this mid-length (11.8A) crosslinker containing maleimide and hydrazide groups.

Thermo Scientific™ Pierce™ SMPT Crosslinker

Crosslink amines to sulfhydryls with this crosslinker containing NHS-ester and pyridyldithiol groups at the ends of an aromatic, 6-atom (11.2A) spacer arm.

Thermo Scientific™ Pierce™ Premium Grade BS3

Crosslink proteins and other biomolecules in applications where product integrity and risk minimization are paramount with Thermo Scientific™ Pierce™ Premium Grade BS3, a high-quality formulation of this popular amine-reactive crosslinker.

Thermo Scientific™ Pierce™ Sulfo-LC-SPDP Crosslinker

Crosslink amines to sulfhydryls with this water-soluble sulfo-NHS-ester and pyridyldithiol groups on 10-atom spacer arms to form cleavable disulfide bonds with cysteines.

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