Crosslinking Reagents

Thermo Scientific™ Pierce™ NHS-Diazirine Crosslinkers Available on GSA/VA Contract for Federal Government customers only.

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

Thermo Scientific™ Pierce™ Sulfo-SBED Biotin Label Transfer Reagent

Chemically tag purified proteins at primary amines to covalently crosslink and transfer biotinylation to protein interaction binding partners.

Thermo Scientific Pierce™ Premium Grade EDC

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular carbodiimide crosslinker.

Thermo Scientific™ Pierce™ Premium Grade BS3

Crosslink proteins and other biomolecules in applications where product integrity and risk minimization are paramount with Thermo Scientific™ Pierce™ Premium Grade BS3, a high-quality formulation of this popular amine-reactive crosslinker.

Thermo Scientific™ Pierce™ TMEA Crosslinker

A 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine; composed of three maleimide groups on short spacer arms; conjugate protein or peptide cysteines.

Thermo Scientific™ Pierce™ SM(PEG)n Crosslinkers Available on GSA/VA Contract for Federal Government customers only.

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Thermo Scientific™ Pierce™ TSAT Crosslinker

A 3-way, short-arm (4.2A) amine-to-amine crosslinker; tris (succinimidyl) aminotriacetate, composed of three NHS-ester groups on short spacer arms; membrane permeable.

Thermo Scientific™ Pierce™ Sulfo-SMCC Crosslinker Available on GSA/VA Contract for Federal Government customers only.

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Thermo Scientific Pierce™ Premium Grade Sulfo-SMCC

Optimize applications where product integrity and risk minimization are paramount our highest quality formulation of this popular amine-to-sulfhydryl crosslinker.

Thermo Scientific™ Pierce™ Sulfo-SBED Biotin Label Transfer WB Kit

Tag a purified protein to covalently crosslink and transfer biotinylation to its binding partner; then detect the results by Western blotting.

Thermo Scientific™ Pierce™ DFDNB Crosslinker

Crosslink amines to amines via stable arylamine bonds using 1,5-difluoro-2,4-dinitrobenzene; an aryl halide compound with a short spacer arm (3.0A) and fluorine atoms.

Thermo Scientific™ Pierce™ SIA Crosslinker

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 3-atom (1.5A) spacer arm.

Thermo Scientific™ Pierce™ MPBH Crosslinker

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this long (17.9A) crosslinker containing maleimide and hydrazide groups.

Thermo Scientific™ Pierce™ EMCS Crosslinker Available on GSA/VA Contract for Federal Government customers only.

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 8-atom (9.4A) spacer arm.

Thermo Scientific™ Pierce™ Sulfo-NHS Crosslinker Available on GSA/VA Contract for Federal Government customers only.

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Thermo Scientific™ Pierce™ DMA Crosslinker

Crosslink amines to amines with dimethyl adipimidate (CAS 14620-72-5); composed of imidoester groups and a 6-atom, membrane-permeable spacer arm.

Thermo Scientific™ Pierce™ Controlled Protein-Protein Crosslinking Kit

Chemically conjugate any two purified proteins (antibodies, enzymes, carriers, etc.) using sulfo-SMCC crosslinker, a complete kit with modification reagents and buffers.

Thermo Scientific™ Pierce™ DSP Crosslinker Available on GSA/VA Contract for Federal Government customers only.

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

Thermo Scientific™ Pierce™ NHS-Azide Staudinger Ligation Reagents Available on GSA/VA Contract for Federal Government customers only.

Activated azido compounds to derivatize proteins or amine surfaces for selective conjugation, detection or purification by phosphine-modified probes.

Thermo Scientific™ Pierce™ AMAS Crosslinker

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 4-atom (4.4A) spacer arm.

Thermo Scientific™ Pierce™ No-Weigh™ Sulfo-SMCC

Format preserves reagent activity and prevents cross-contamination between uses

Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Thermo Scientific™ Pierce™ Premium Grade SPDP

Crosslink proteins and other biomolecules in applications where product integrity and risk minimization are paramount with Thermo Scientific™ Pierce™ Premium Grade SPDP, a high-quality formulation of this popular pyridyldithiol-based amine-to-sulfhydryl crosslinker.

Thermo Scientific™ Pierce™ SIAB Crosslinker

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 9-atom (10.6A) aminobenzoate spacer arm.

Thermo Scientific™ Pierce™ SMCC Crosslinker

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of a stabilizing cyclohexane-containing, 8-atom spacer arm.

Thermo Scientific™ Pierce™ Premium Grade DSP

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

Thermo Scientific™ Pierce™ ANB-NOS Crosslinker

Crosslink amines to anything witht this short, photoreactive crosslinker with NHS-ester and nitrophenyl azide reactive groups; photoactivates with UV light (Amax 320nm).

Thermo Scientific™ Pierce™ EDC Crosslinker Available on GSA/VA Contract for Federal Government customers only.

Immobilize or conjugate proteins using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (CAS 25952-53-8), a water-soluble, carboxyl-to-amine crosslinker.

Thermo Scientific™ Pierce™ Sulfo-KMUS Crosslinker

Crosslink amines to sulfhydryls with this long crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aliphatic, 13-atom (16.3A) spacer arm.

Thermo Scientific™ Pierce™ Sulfo-GMBS Crosslinker

Crosslink amines to sulfhydryls with this short, water-soluble crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aliphatic, 6-atom (7.3A) spacer arm.

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