Hs00043307_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57517759 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428283	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	MIR6758 MIR616 DDIT3 DTX3 ARHGAP9 PIP4K2C INHBE KIF5A DCTN2 GLI1 MBD6 INHBC MARS
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	MIR6758 MIR616 DDIT3 DTX3 ARHGAP9 LOC101927583 PIP4K2C KIF5A DCTN2 GLI1 ARHGEF25 MBD6 MARS
nsv469411	Chr.12:57450266 - 57527405 on Build GRCh38	Loss	MIR6758 INHBE MIR616 DDIT3 GLI1 MBD6 ARHGAP9 INHBC MARS
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	MIR616 DDIT3 MBD6
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	MIR616 ARHGAP9 LOC101927583 NABP2 SNORD59A CNPY2 SLC39A5 RDH16 OS9 GLS2 NEMP1 MIP ZBTB39 TIMELESS TAC3 BAZ2A SPRYD4 PAN2 COQ10A IL23A KIF5A CS GPR182 PTGES3 NACA STAT6 LRP1-AS MIR6758 B4GALNT1 DDIT3 STAC3 MYO1A LRP1 HSD17B6 SNORD59B PIP4K2C SLC26A10 INHBE NAB2 DCTN2 SNORA105C MBD6 SHMT2 NDUFA4L2 HBCBP ANKRD52 RBMS2 MIR1228 DTX3 RNF41 PRIM1 ATP5B R3HDM2 SDR9C7 NXPH4 GLI1 ARHGEF25 INHBC STAT2 MARS APOF

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity