Hs00043307_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57517759 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759901	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	MIR6758 GLI1 PIP4K2C INHBE DTX3 INHBC MIR616 DCTN2 DDIT3 MARS MBD6 ARHGAP9 KIF5A
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	MIR6758 GLI1 PIP4K2C ARHGEF25 DTX3 MIR616 DCTN2 LOC101927583 DDIT3 MARS MBD6 ARHGAP9 KIF5A
dgv2651n54	Chr.12:57450266 - 57552694 on Build GRCh38	Loss	INHBC MIR616 DCTN2 DDIT3 MIR6758 MARS MBD6 GLI1 ARHGAP9 KIF5A INHBE
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	HSD17B6 STAT6 IL23A ZBTB39 NXPH4 MIR6758 TAC3 PIP4K2C SDR9C7 NABP2 PTGES3 MARS SNORD59A NEMP1 STAC3 HBCBP MYO1A B4GALNT1 LRP1 GPR182 R3HDM2 SLC26A10 RBMS2 ARHGEF25 DTX3 DDIT3 MIR1228 APOF PRIM1 SNORA105C SPRYD4 RDH16 NACA ATP5B NDUFA4L2 TIMELESS COQ10A SHMT2 INHBE PAN2 GLS2 MIR616 DCTN2 STAT2 ANKRD52 BAZ2A NAB2 OS9 MBD6 ARHGAP9 CS SLC39A5 GLI1 SNORD59B LRP1-AS INHBC LOC101927583 RNF41 MIP CNPY2 KIF5A
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	MIR616 DDIT3 MBD6

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity