Hs00082738_cn

• Gene Symbol: PRODH
• Assay Reference Genome Location: Chr.22:18925695 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 5625
• Gene Name: proline dehydrogenase 1
• Gene Aliases: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
• Location: Chr.22:18912774-18936553 on Build GRCh38
• Assay Gene Location: Overlaps Intron 3 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRODH	NM_001195226.1			NP_001182155.1
	NM_016335.4			NP_057419.4
	BC118597.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32687	Chr.22:18158909 - 19022965 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A TMEM191B DGCR10 LOC102725072 DGCR5 USP18 GGT3P
dgv7977n54	Chr.22:18913491 - 19020595 on Build GRCh38	Gain	PRODH DGCR9 DGCR5
dgv4472n100	Chr.22:18888903 - 19037700 on Build GRCh38	Loss	DGCR10 PRODH DGCR9 DGCR6 DGCR5 LOC100996432 DGCR2
nsv953020	Chr.22:18899988 - 18938787 on Build GRCh38	Deletion	PRODH DGCR6
nsv588203	Chr.22:18925165 - 19020595 on Build GRCh38	Gain+Loss	PRODH DGCR9 DGCR5
esv3584483	Chr.22:18782908 - 19018612 on Build GRCh38	Gain	PRODH DGCR9 LOC102725072 DGCR6 DGCR5 LOC100996432 GGT3P
esv2751935	Chr.22:18149609 - 19042823 on Build GRCh38	Loss	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A DGCR2 TMEM191B DGCR10 LOC102725072 DGCR5 USP18 GGT3P
nsv588155	Chr.22:18795358 - 19020595 on Build GRCh38	Gain	PRODH DGCR9 LOC102725072 DGCR6 DGCR5 LOC100996432
dgv542n27	Chr.22:18890274 - 19020595 on Build GRCh38	Loss	PRODH DGCR9 DGCR6 DGCR5 LOC100996432
nsv1063432	Chr.22:18902533 - 18929331 on Build GRCh38	Loss	PRODH DGCR6
nsv516997	Chr.22:18143870 - 19039100 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A DGCR2 TMEM191B DGCR10 LOC102725072 DGCR5 USP18 GGT3P
dgv7969n54	Chr.22:18874235 - 19046019 on Build GRCh38	Gain	DGCR10 PRODH DGCR9 DGCR6 DGCR5 LOC100996432 DGCR2
dgv1283e212	Chr.22:18166100 - 19017223 on Build GRCh38	Gain	PI4KAP1 PRODH LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A TMEM191B LOC102725072 DGCR5 USP18 GGT3P
dgv99e203	Chr.22:18173093 - 19019471 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A TMEM191B LOC102725072 DGCR5 USP18 GGT3P
dgv4476n100	Chr.22:18899376 - 19019471 on Build GRCh38	Gain	PRODH DGCR9 DGCR6 DGCR5
nsv442503	Chr.22:18822597 - 19018611 on Build GRCh38	Gain	PRODH DGCR9 LOC102725072 DGCR6 DGCR5 LOC100996432
esv2758824	Chr.22:18069029 - 19074200 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 DGCR11 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A DGCR2 TMEM191B DGCR10 LOC102725072 DGCR5 PEX26 USP18 GGT3P TUBA8
esv3893432	Chr.22:18750783 - 19029150 on Build GRCh38	Gain	DGCR10 PRODH DGCR9 LOC102725072 DGCR6 DGCR5 LOC100996432 LOC642643 GGT3P
dgv173e55	Chr.22:18157533 - 19070277 on Build GRCh38	Gain	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 DGCR11 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A DGCR2 TMEM191B DGCR10 LOC102725072 DGCR5 USP18 GGT3P
dgv4467n100	Chr.22:18166204 - 19019471 on Build GRCh38	Gain	PI4KAP1 PRODH DGCR9 LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A TMEM191B LOC102725072 DGCR5 USP18 GGT3P
dgv42e213	Chr.22:18888915 - 19019471 on Build GRCh38	Gain	PRODH DGCR9 DGCR6 DGCR5 LOC100996432
dgv169n111	Chr.22:18745406 - 19019471 on Build GRCh38	Duplication	PRODH DGCR9 LOC102725072 DGCR6 DGCR5 LOC100996432 LOC642643 GGT3P
dgv4469n100	Chr.22:18760915 - 19037281 on Build GRCh38	Gain	DGCR10 PRODH DGCR9 LOC102725072 DGCR6 DGCR5 LOC100996432 GGT3P DGCR2
dgv7975n54	Chr.22:18901977 - 19029150 on Build GRCh38	Loss	DGCR10 PRODH DGCR9 DGCR6 DGCR5
esv3647250	Chr.22:18924644 - 19011486 on Build GRCh38	Gain	PRODH DGCR5
nsv588201	Chr.22:18922407 - 18959084 on Build GRCh38	Loss	PRODH
dgv174e55	Chr.22:18903433 - 19050022 on Build GRCh38	Gain	DGCR10 PRODH DGCR9 DGCR6 DGCR11 DGCR5 DGCR2
esv3584485	Chr.22:18806434 - 18964032 on Build GRCh38	Gain	PRODH LOC102725072 DGCR6 LOC100996432
nsv1067175	Chr.22:18822569 - 19046938 on Build GRCh38	Loss	DGCR10 PRODH DGCR9 LOC102725072 DGCR6 DGCR11 DGCR5 LOC100996432 DGCR2
nsv1160726	Chr.22:18899868 - 19019471 on Build GRCh38	Duplication	PRODH DGCR9 DGCR6 DGCR5
nsv979632	Chr.22:18908034 - 18929580 on Build GRCh38	Duplication	PRODH DGCR6
esv22247	Chr.22:18174171 - 18937942 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH LOC100996415 DGCR6 LOC729461 LOC100996432 LOC642643 LOC100996401 RIMBP3 FAM230A TMEM191B LOC102725072 USP18 GGT3P
dgv7976n54	Chr.22:18903102 - 18988074 on Build GRCh38	Gain	PRODH DGCR6 DGCR5
esv3575418	Chr.22:18161776 - 19963846 on Build GRCh38	Gain	TBX1 MRPL40 C22orf29 GSC2 RIMBP3 FAM230A DGCR2 DGCR10 SEPT5-GP1BB DGCR5 SLC25A1 TXNRD2 LINC01311 CLTCL1 CDC45 TSSK2 UFD1L COMT HIRA PI4KAP1 PRODH DGCR9 C22orf39 LOC100996415 DGCR6 DGCR11 LOC729461 LOC100996432 SEPT5 MIR4761 LOC642643 LOC100996401 TMEM191B CLDN5 LOC102725072 GP1BB LINC00895 DGCR14 USP18 GGT3P GNB1L

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidase

Gene Ontology Categories:

Process(es)

proline metabolic process
proline catabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
proline catabolic process to glutamate
positive regulation of cell death
4-hydroxyproline catabolic process
oxidation-reduction process

Function(s)

proline dehydrogenase activity
FAD binding