Hs00131541_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57520377 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759901	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	KIF5A MARS MBD6 INHBC MIR616 DCTN2 DTX3 DDIT3 INHBE ARHGAP9 PIP4K2C MIR6758 GLI1
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	ARHGEF25 LOC101927583 KIF5A MARS MBD6 MIR616 DCTN2 DTX3 DDIT3 ARHGAP9 PIP4K2C MIR6758 GLI1
dgv2651n54	Chr.12:57450266 - 57552694 on Build GRCh38	Loss	DDIT3 KIF5A MARS MBD6 INHBC INHBE MIR616 DCTN2 ARHGAP9 MIR6758 GLI1
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	NAB2 PTGES3 KIF5A GLS2 NDUFA4L2 TIMELESS PAN2 LRP1 SNORA105C MYO1A SHMT2 NEMP1 BAZ2A CNPY2 PIP4K2C STAC3 CS ZBTB39 ARHGEF25 R3HDM2 MARS IL23A RDH16 STAT6 PRIM1 ATP5B TAC3 LRP1-AS NACA ANKRD52 SLC39A5 GLI1 HSD17B6 SNORD59A NXPH4 HBCBP RBMS2 DCTN2 SLC26A10 SPRYD4 DDIT3 SNORD59B INHBE ARHGAP9 MIR1228 LOC101927583 MIP RNF41 MBD6 SDR9C7 INHBC MIR616 NABP2 OS9 STAT2 DTX3 GPR182 COQ10A B4GALNT1 MIR6758 APOF
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	DDIT3 MBD6 MIR616

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity