Hs00131541_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57520377 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428283	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	ARHGAP9 MARS DTX3 INHBE PIP4K2C DCTN2 DDIT3 MIR6758 INHBC GLI1 MIR616 MBD6 KIF5A
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	ARHGAP9 MARS DTX3 LOC101927583 PIP4K2C DCTN2 DDIT3 ARHGEF25 MIR6758 GLI1 MIR616 MBD6 KIF5A
nsv469411	Chr.12:57450266 - 57527405 on Build GRCh38	Loss	ARHGAP9 MARS MIR6758 INHBC INHBE GLI1 MIR616 DDIT3 MBD6
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	MIR616 DDIT3 MBD6
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	APOF ARHGAP9 NDUFA4L2 CNPY2 MARS R3HDM2 SLC26A10 GLS2 IL23A PTGES3 PIP4K2C STAC3 SHMT2 DCTN2 RBMS2 SNORA105C RDH16 ANKRD52 TAC3 STAT6 HSD17B6 MIR616 OS9 NXPH4 SPRYD4 NACA PRIM1 SNORD59B ARHGEF25 PAN2 HBCBP STAT2 MBD6 KIF5A MYO1A DTX3 INHBE LOC101927583 LRP1-AS DDIT3 COQ10A SNORD59A INHBC B4GALNT1 GLI1 RNF41 CS LRP1 MIR1228 ATP5B SLC39A5 TIMELESS NABP2 BAZ2A MIR6758 MIP SDR9C7 NEMP1 NAB2 GPR182 ZBTB39

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity