Hs00223449_cn

• Gene Symbol: HTR2C
• Assay Reference Genome Location: Chr.X:114613830 on build GRCh38
• Cytoband: Xq23

Target Gene Details

• Entrez Gene ID: 3358
• Gene Name: 5-hydroxytryptamine receptor 2C
• Gene Aliases: 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
• Location: Chr.X:114584078-114910061 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HTR2C	NM_000868.3			NP_000859.1
	NM_001256760.2			NP_001243689.1
	NM_001256761.2			NP_001243690.1
	AK295753.1
	AK308766.1
	M81778.1			AAA60317.1
	U49516.1			AAB40898.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3574320	Chr.X:114607663 - 114619561 on Build GRCh38	Loss	HTR2C
nsv527347	Chr.X:114537428 - 114983201 on Build GRCh38	Gain	MIR1298 HTR2C MIR764 SNORA35 MIR448 MIR1911 MIR1912 MIR1264
esv33994	Chr.X:113685854 - 115738426 on Build GRCh38	Gain+Loss	MIR1298 MIR764 SNORA35 LUZP4 MIR448 MIR1911 MIR1912 LRCH2 MIR1264 RBMXL3 LOC105373314 HTR2C PLS3 IL13RA2 PLS3-AS1
dgv524n21	Chr.X:114067803 - 114619628 on Build GRCh38	Gain	HTR2C

More Information

Additional Information:

For this assay, SNP(s) [rs147717921] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

behavioral fear response
cGMP biosynthetic process
cellular calcium ion homeostasis
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
locomotory behavior
feeding behavior
positive regulation of phosphatidylinositol biosynthetic process
regulation of neurological system process
regulation of appetite
response to drug
regulation of corticotropin-releasing hormone secretion
positive regulation of fat cell differentiation
release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of ERK1 and ERK2 cascade

Function(s)

Gq/11-coupled serotonin receptor activity
G-protein coupled serotonin receptor activity
drug binding
serotonin binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding