Hs00305442_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96113244 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	3002	NP_000673.2
	BC133021.1	1	3002
	BC136537.1	1	3002

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	CIAO1 LOC105373496 LOC653924 ANKRD39 FAHD2CP LOC100506076 STARD7-AS1 FER1L5 ITPRIPL1 FAHD2B ANKRD23 MIR3127 DUSP2 STARD7 NEURL3 NCAPH CNNM4 LOC105373495 GPAT2 LOC100506123 LOC107984110 ASTL SNRNP200 LOC101927053 ADRA2B SEMA4C ANKRD36C ARID5A FAM178B LMAN2L CNNM3 ANKRD36 KANSL3 ANKRD36B TMEM127
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	ASTL DUSP2 ADRA2B
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	CIAO1 LOC105373496 LOC653924 ANKRD39 FAHD2CP LOC100506076 STARD7-AS1 FER1L5 ITPRIPL1 FAHD2B ANKRD23 MIR3127 DUSP2 STARD7 NEURL3 NCAPH CNNM4 LOC105373495 GPAT2 LOC100506123 LOC107984110 ASTL SNRNP200 LOC101927053 ADRA2B SEMA4C ANKRD36C ARID5A FAM178B LMAN2L CNNM3 ANKRD36 KANSL3 ANKRD36B TMEM127
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	CIAO1 LOC105373496 LOC653924 ANKRD39 FAHD2CP LOC100506076 STARD7-AS1 FER1L5 ITPRIPL1 FAHD2B ANKRD23 MIR3127 DUSP2 STARD7 NEURL3 NCAPH CNNM4 LOC105373495 GPAT2 LOC100506123 LOC107984110 ASTL SNRNP200 LOC101927053 ADRA2B SEMA4C ANKRD36C ARID5A FAM178B LMAN2L CNNM3 ANKRD36 KANSL3 ANKRD36B TMEM127

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding