Hs00306742_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4257945 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Within Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2	7	1381	NP_003214.1
	XM_011522633.2	7	1517	XP_011520935.1
	XM_011522635.2	7	1197	XP_011520937.1
	AB209146.1	5	5732	BAD92383.1
	BC010576.1	7	1270	AAH10576.1
	S73885.1	7	1385	AAB32235.1
	X57435.1	7	1076	CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	EEF2KMT GLIS2 GLYR1 LINC01569 ALG1 SRL TFAP4 CDIP1 UBALD1 ROGDI NAGPA ADCY9 PPL NAGPA-AS1 UBN1 SEC14L5 C16orf96 ANKS3 ZNF500 MIR6769A CORO7 NUDT16L1 VASN SMIM22 LOC105371063 NMRAL1 RBFOX1 SEPT12 HMOX2 C16orf89 MGRN1 GLIS2-AS1 CORO7-PAM16 PAM16 DNAJA3 C16orf71
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	LOC102724927 CREBBP ADCY9 LINC01569 LOC105371063 SRL TFAP4
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	CORO7 GLIS2 VASN LINC01569 GLIS2-AS1 LOC105371063 CORO7-PAM16 SRL PAM16 TFAP4

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding