Hs00321103_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96113069 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	3177	NP_000673.2
	AA887330.1
	BC133021.1	1	3177
	BC136537.1	1	3177

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	CIAO1 KANSL3 FAHD2B DUSP2 GPAT2 LOC101927053 ANKRD36B SEMA4C LOC105373495 ANKRD23 NEURL3 STARD7 CNNM4 ANKRD36C SNRNP200 ANKRD39 ITPRIPL1 ADRA2B CNNM3 ARID5A TMEM127 LOC100506076 LOC653924 LOC107984110 LMAN2L LOC100506123 FER1L5 NCAPH ANKRD36 ASTL FAHD2CP MIR3127 FAM178B STARD7-AS1 LOC105373496
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	DUSP2 ASTL ADRA2B
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	CIAO1 KANSL3 FAHD2B DUSP2 GPAT2 LOC101927053 ANKRD36B SEMA4C LOC105373495 ANKRD23 NEURL3 STARD7 CNNM4 ANKRD36C SNRNP200 ANKRD39 ITPRIPL1 ADRA2B CNNM3 ARID5A TMEM127 LOC100506076 LOC653924 LOC107984110 LMAN2L LOC100506123 FER1L5 NCAPH ANKRD36 ASTL FAHD2CP MIR3127 FAM178B STARD7-AS1 LOC105373496
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	CIAO1 KANSL3 FAHD2B DUSP2 GPAT2 LOC101927053 ANKRD36B SEMA4C LOC105373495 ANKRD23 NEURL3 STARD7 CNNM4 ANKRD36C SNRNP200 ANKRD39 ITPRIPL1 ADRA2B CNNM3 ARID5A TMEM127 LOC100506076 LOC653924 LOC107984110 LMAN2L LOC100506123 FER1L5 NCAPH ANKRD36 ASTL FAHD2CP MIR3127 FAM178B STARD7-AS1 LOC105373496

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding