Hs00323100_cn

• Gene Symbol: IL10
• Assay Reference Genome Location: Chr.1:206772427 on build GRCh38
• Cytoband: 1q32.1

Target Gene Details

• Entrez Gene ID: 3586
• Gene Name: interleukin 10
• Gene Aliases: CSIF, GVHDS, IL-10, IL10A, TGIF
• Location: Chr.1:206767603-206772494 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IL10	NM_000572.2	1	68	NP_000563.1
	AY029171.1			AAK38162.1
	BC104252.1	1	65	AAI04253.1
	BC104253.1	1	65	AAI04254.1
	CR541993.1			CAG46790.1
	CR542028.1			CAG46825.1
	EU751618.2
	EU751619.2
	M57627.1			AAA63207.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3578391	Chr.1:206770892 - 206779577 on Build GRCh38	Loss	IL10

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to molecule of bacterial origin
negative regulation of cytokine secretion involved in immune response
negative regulation of chronic inflammatory response to antigenic stimulus
positive regulation of B cell apoptotic process
inflammatory response
cytoplasmic sequestering of NF-kappaB
cell-cell signaling
aging
regulation of gene expression
response to activity
response to inactivity
hemopoiesis
B cell differentiation
leukocyte chemotaxis
negative regulation of myeloid dendritic cell activation
negative regulation of B cell proliferation
negative regulation of interferon-gamma production
negative regulation of interleukin-1 production
negative regulation of interleukin-12 production
negative regulation of interleukin-18 production
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
receptor biosynthetic process
response to insulin
response to carbon monoxide
cellular response to hepatocyte growth factor stimulus
type 2 immune response
B cell proliferation
negative regulation of T cell proliferation
response to drug
negative regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
defense response to protozoan
negative regulation of apoptotic process
negative regulation of growth of symbiont in host
negative regulation of nitric oxide biosynthetic process
regulation of isotype switching
negative regulation of MHC class II biosynthetic process
positive regulation of MHC class II biosynthetic process
negative regulation of interferon-alpha biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
positive regulation of cytokine secretion
negative regulation of membrane protein ectodomain proteolysis
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
regulation of sensory perception of pain
negative regulation of cytokine activity
branching involved in labyrinthine layer morphogenesis
cellular response to lipopolysaccharide
cellular response to estradiol stimulus
negative regulation of chemokine (C-C motif) ligand 5 production
regulation of complement-dependent cytotoxicity
negative regulation of endothelial cell apoptotic process

Function(s)

cytokine activity
interleukin-10 receptor binding
protein binding
growth factor activity