Hs00339745_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4262577 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Within Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2	2	468	NP_003214.1
	XM_011522633.2	2	604	XP_011520935.1
	XM_011522635.2	2	284	XP_011520937.1
	AB209146.1	1	4611	BAD92383.1
	AK309301.1	2	535
	BC010576.1	2	357	AAH10576.1
	BU159415.1	2	421
	CR541726.1	2	214	CAG46527.1
	DA449763.1
	S73885.1	2	472	AAB32235.1
	X57435.1	2	163	CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	NAGPA MIR6769A NMRAL1 ROGDI VASN GLYR1 UBN1 ADCY9 UBALD1 SMIM22 EEF2KMT C16orf96 RBFOX1 HMOX2 C16orf89 C16orf71 SEC14L5 TFAP4 SEPT12 NUDT16L1 DNAJA3 LINC01569 GLIS2-AS1 PAM16 CORO7 SRL CDIP1 ZNF500 LOC105371063 MGRN1 ANKS3 CORO7-PAM16 PPL ALG1 NAGPA-AS1 GLIS2
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	LOC105371063 TFAP4 ADCY9 LINC01569 CREBBP LOC102724927 SRL
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	LOC105371063 TFAP4 LINC01569 CORO7-PAM16 GLIS2-AS1 PAM16 VASN CORO7 SRL GLIS2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding