Hs00341346_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96114179 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	2067	NP_000673.2
	BC133021.1	1	2067
	BC136537.1	1	2067
	BF475329.1	1	297

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	CNNM4 ANKRD39 ANKRD23 FAHD2CP DUSP2 FAHD2B LMAN2L LOC101927053 TMEM127 ASTL ITPRIPL1 LOC653924 STARD7 LOC107984110 ANKRD36 FAM178B GPAT2 STARD7-AS1 MIR3127 ANKRD36B FER1L5 NCAPH LOC105373495 SNRNP200 CNNM3 SEMA4C CIAO1 ANKRD36C LOC100506123 KANSL3 LOC100506076 ADRA2B LOC105373496 ARID5A NEURL3
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	ASTL ADRA2B DUSP2
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	CNNM4 ANKRD39 ANKRD23 FAHD2CP DUSP2 FAHD2B LMAN2L LOC101927053 TMEM127 ASTL ITPRIPL1 LOC653924 STARD7 LOC107984110 ANKRD36 FAM178B GPAT2 STARD7-AS1 MIR3127 ANKRD36B FER1L5 NCAPH LOC105373495 SNRNP200 CNNM3 SEMA4C CIAO1 ANKRD36C LOC100506123 KANSL3 LOC100506076 ADRA2B LOC105373496 ARID5A NEURL3
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	CNNM4 ANKRD39 ANKRD23 FAHD2CP DUSP2 FAHD2B LMAN2L LOC101927053 TMEM127 ASTL ITPRIPL1 LOC653924 STARD7 LOC107984110 ANKRD36 FAM178B GPAT2 STARD7-AS1 MIR3127 ANKRD36B FER1L5 NCAPH LOC105373495 SNRNP200 CNNM3 SEMA4C CIAO1 ANKRD36C LOC100506123 KANSL3 LOC100506076 ADRA2B LOC105373496 ARID5A NEURL3

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding