Hs00370952_cn

• Gene Symbol: PIDD1
• Assay Reference Genome Location: Chr.11:801229 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 55367
• Gene Name: p53-induced death domain protein 1
• Gene Aliases: LRDD, PIDD
• Location: Chr.11:799179-809504 on Build GRCh38
• Assay Gene Location: Overlaps Intron 10 - Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PIDD1	NM_145886.3			NP_665893.2
	NM_145887.3			NP_665894.2
	XM_005253005.4			XP_005253062.1
	XM_005253006.4			XP_005253063.1
	XM_005253007.3			XP_005253064.1
	XM_005253008.4			XP_005253065.1
	XM_011520209.2			XP_011518511.1
	XM_011520210.2			XP_011518512.1
	XM_011520211.2			XP_011518513.1
	XM_011520212.1			XP_011518514.1
	XM_011520213.2			XP_011518515.1
	XM_017017993.1			XP_016873482.1
	AB208832.1			BAD92069.1
	AB208949.1			BAD92186.1
	AB209529.1			BAD92766.1
	AF229178.1			AAF69491.1
	AF274972.1			AAG13461.1
	AF465246.1			AAP97716.1
	AK074893.1			BAC11272.1
	AL833849.1			CAD38708.1
	BC014904.1			AAH14904.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv552871	Chr.11:766479 - 870446 on Build GRCh38	Loss	POLR2L PDDC1 CRACR2B SLC25A22 LOC171391 TSPAN4 PANO1 SNORA52 PNPLA2 PIDD1 CHID1 RPLP2 CD151 CEND1
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	POLR2L CRACR2B DEAF1 SLC25A22 SCT LOC171391 LRRC56 SIGIRR LOC101059906 TSPAN4 B4GALNT4 MIR210HG TOLLIP PIDD1 HRAS ANO9 MUC5AC TALDO1 LOC101927503 PTDSS2 CD151 CDHR5 MUC5B IRF7 AP2A2 PHRF1 PDDC1 MIR210 TMEM80 MUC2 MIR6744 MUC6 PANO1 SNORA52 PNPLA2 LOC143666 CHID1 EPS8L2 RNH1 RPLP2 PKP3 RASSF7 CEND1 DRD4 LMNTD2
dgv1013n100	Chr.11:772982 - 933569 on Build GRCh38	Gain	AP2A2 POLR2L PDDC1 CRACR2B SLC25A22 LOC171391 TSPAN4 PANO1 SNORA52 PNPLA2 PIDD1 CHID1 RPLP2 CD151 CEND1
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	POLR2L CRACR2B DEAF1 SLC25A22 SCT LOC171391 LRRC56 SIGIRR LOC101059906 TSPAN4 MIR210HG TOLLIP PIDD1 HRAS ANO9 MUC5AC TALDO1 TOLLIP-AS1 LOC101927503 PTDSS2 CD151 CDHR5 MUC5B IRF7 AP2A2 PHRF1 PDDC1 MIR210 TMEM80 MUC2 MIR6744 MUC6 PANO1 SNORA52 PNPLA2 LOC143666 CHID1 EPS8L2 RNH1 RPLP2 RASSF7 CEND1 DRD4 LMNTD2
nsv1040044	Chr.11:776335 - 900929 on Build GRCh38	Gain+Loss	POLR2L PDDC1 CRACR2B SLC25A22 LOC171391 TSPAN4 PANO1 SNORA52 PNPLA2 PIDD1 CHID1 RPLP2 CD151 CEND1
nsv552870	Chr.11:743813 - 810882 on Build GRCh38	Loss	PDDC1 PIDD1 SLC25A22 RPLP2 LOC171391 TALDO1 PANO1 CEND1
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	POLR2L CRACR2B DEAF1 SLC25A22 SCT LOC171391 LRRC56 SIGIRR LOC101059906 TSPAN4 B4GALNT4 MIR210HG PIDD1 HRAS ANO9 TALDO1 PTDSS2 CD151 CDHR5 IRF7 AP2A2 PHRF1 PDDC1 MIR210 TMEM80 PANO1 SNORA52 PNPLA2 LOC143666 CHID1 EPS8L2 RNH1 RPLP2 PKP3 RASSF7 CEND1 DRD4 LMNTD2
nsv8759	Chr.11:775539 - 835248 on Build GRCh38	Gain	PDDC1 CRACR2B PIDD1 SLC25A22 RPLP2 LOC171391 PANO1 CD151 SNORA52 CEND1 PNPLA2
nsv1159791	Chr.11:461793 - 909492 on Build GRCh38	Deletion	POLR2L CRACR2B DEAF1 SLC25A22 SCT LOC171391 LRRC56 LOC101059906 TSPAN4 MIR210HG PIDD1 HRAS TALDO1 PTDSS2 CD151 CDHR5 IRF7 PHRF1 PDDC1 MIR210 TMEM80 PANO1 SNORA52 PNPLA2 LOC143666 CHID1 EPS8L2 RNH1 RPLP2 RASSF7 CEND1 DRD4 LMNTD2
nsv951272	Chr.11:751201 - 911500 on Build GRCh38	Deletion	POLR2L PDDC1 CRACR2B SLC25A22 LOC171391 TSPAN4 PANO1 SNORA52 PNPLA2 PIDD1 CHID1 RPLP2 TALDO1 CD151 CEND1

More Information

Additional Information:

For this assay, SNP(s) [rs115365647] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of NF-kappaB transcription factor activity
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

death receptor binding
protein binding