Hs00390257_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31656644 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Overlaps Exon 3 - Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NM_019101.2			NP_061974.2
	NR_045828.1
	XM_006715150.3			XP_006715213.1
	AA846749.1
	AF118393.3			AAD11443.2
	AF161454.1			AAF29014.1
	AJ245434.1			CAB51604.1
	BC020683.1			AAH20683.1
	BF344944.1
	BG564719.1
	CB054016.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_017011279.1			XP_016866768.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	NELFE DDX39B-AS1 C6orf47 MIR6721 MICB PRRC2A CYP21A2 SNORD48 LOC100287329 CLIC1 ATP6V1G2-DDX39B AIF1 SAPCD1 PBX2 ATP6V1G2 EHMT2 C2 TNF LTB VWA7 MIR4646 HLA-DRB1 RNF5 NCR3 PRRT1 HCP5 NFKBIL1 LY6G6F FKBPL NOTCH4 LY6G6D AGPAT1 ATF6B LY6G5C SLC44A4 HCG26 C6orf48 APOM CFB C4A HLA-DRA VARS AGER LST1 PPT2-EGFL8 HSPA1L LOC102725068 HSPA1B DDAH2 HSPA1A MSH5-SAPCD1 C2-AS1 TNXA MIR6832 SNORD117 NEU1 MSH5 LY6G6E EGFL8 HLA-DRB5 GPSM3 BAG6 ZBTB12 STK19 C4B SNORD84 LOC101929163 BTNL2 MIR1236 SNORD52 CSNK2B HLA-DRB6 LY6G6C LTA MIR6833 TNXB LSM2 LY6G5B DXO HCG23 GPANK1 SKIV2L MCCD1 SNORA38 LOC100507547 CYP21A1P ABHD16A SAPCD1-AS1 C6orf10 PPT2 C6orf25 DDX39B
nsv601942	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	APOM C6orf47 SNORA38 PRRC2A BAG6 MIR6832 AIF1 GPANK1
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	NELFE DDX39B-AS1 C6orf47 MICB PRRC2A CYP21A2 SNORD48 LOC100287329 CLIC1 ATP6V1G2-DDX39B AIF1 SAPCD1 ATP6V1G2 EHMT2 C2 TNF LTB VWA7 MIR4646 NCR3 HCP5 NFKBIL1 LY6G6F LY6G6D MICA LY6G5C SLC44A4 HCG26 C6orf48 APOM CFB C4A VARS LST1 HSPA1L LOC102725068 HSPA1B DDAH2 HSPA1A MSH5-SAPCD1 C2-AS1 TNXA MIR6832 SNORD117 NEU1 MSH5 LY6G6E HLA-B BAG6 ZBTB12 STK19 C4B SNORD84 MIR1236 SNORD52 MIR6891 CSNK2B LY6G6C LTA TNXB LSM2 LY6G5B DXO GPANK1 SKIV2L MCCD1 SNORA38 CYP21A1P ABHD16A SAPCD1-AS1 C6orf25 DDX39B
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	NELFE DDX39B-AS1 COL11A2 C6orf47 MIR6721 CYP21A2 SNORD48 LOC100287329 CLIC1 AIF1 SAPCD1 ATP6V1G2 EHMT2 C2 TNF VWA7 MIR4646 HLA-DRB1 KIFC1 TAP1 RNF5 NCR3 HCP5 MIR5004 LY6G6F FKBPL HCG24 NOTCH4 ZBTB22 AGPAT1 ATF6B HSD17B8 HCG25 SLC44A4 HCG26 APOM AGER HLA-DMA PPT2-EGFL8 DAXX HLA-DQA1 LOC100294145 HSPA1L HSPA1A SNORD117 NEU1 LY6G6E MIR219A1 HLA-DRB5 GPSM3 BAG6 ZBTB12 STK19 SNORD84 CUTA BTNL2 MIR1236 SNORD52 MIR3135B PSMB8 CSNK2B PPP1R2P1 HLA-DRB6 LTA MIR6833 TNXB LSM2 LY6G5B DXO HLA-DPB2 HCG23 VPS52 LOC100507547 CYP21A1P ABHD16A SAPCD1-AS1 SLC39A7 C6orf10 TAPBP RXRB MIR6834 HLA-DPB1 MICB PRRC2A HLA-DOB ATP6V1G2-DDX39B HLA-DQB1 PBX2 HLA-DMB HLA-DQA2 PSMB9 LTB RPS18 PRRT1 NFKBIL1 RGL2 LY6G6D PFDN6 HLA-DQB1-AS1 LY6G5C C6orf48 CFB C4A HLA-DRA VARS PSMB8-AS1 PHF1 LST1 TAP2 RING1 LOC102725068 HSPA1B DDAH2 MSH5-SAPCD1 C2-AS1 TNXA MIR6832 SYNGAP1 HLA-DOA B3GALT4 MSH5 EGFL8 MIR6873 HLA-DPA1 C4B LOC101929163 LY6G6C ZBTB9 BRD2 GPANK1 SKIV2L MCCD1 SNORA38 WDR46 HLA-DQB2 PPT2 C6orf25 DDX39B
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	NELFE DDX39B-AS1 COL11A2 C6orf47 MIR6721 CYP21A2 SNORD48 LOC100287329 CLIC1 AIF1 SAPCD1 ATP6V1G2 EHMT2 C2 TNF VWA7 MIR4646 HLA-DRB1 KIFC1 TAP1 RNF5 NCR3 HCP5 MIR5004 LY6G6F FKBPL HCG24 NOTCH4 ZBTB22 AGPAT1 ATF6B HSD17B8 HCG25 SLC44A4 HCG26 APOM AGER HLA-DMA PPT2-EGFL8 DAXX HLA-DQA1 LOC100294145 HSPA1L HSPA1A SNORD117 NEU1 LY6G6E MIR219A1 HLA-DRB5 GPSM3 BAG6 ZBTB12 STK19 SNORD84 CUTA BTNL2 MIR1236 SNORD52 MIR3135B PSMB8 CSNK2B PPP1R2P1 HLA-DRB6 LTA MIR6833 TNXB LSM2 LY6G5B DXO HLA-DPB2 HCG23 VPS52 LOC100507547 CYP21A1P ABHD16A SAPCD1-AS1 SLC39A7 C6orf10 TAPBP RXRB MIR6834 HLA-DPB1 MICB PRRC2A HLA-DOB ATP6V1G2-DDX39B HLA-DQB1 PBX2 HLA-DMB HLA-DQA2 PSMB9 LTB RPS18 PRRT1 NFKBIL1 RGL2 LY6G6D PFDN6 HLA-DQB1-AS1 LY6G5C C6orf48 CFB C4A HLA-DRA VARS PSMB8-AS1 PHF1 LST1 TAP2 RING1 LOC102725068 HSPA1B DDAH2 MSH5-SAPCD1 C2-AS1 TNXA MIR6832 SYNGAP1 HLA-DOA B3GALT4 MSH5 EGFL8 MIR6873 HLA-DPA1 C4B LOC101929163 LY6G6C ZBTB9 BRD2 GPANK1 SKIV2L MCCD1 SNORA38 WDR46 HLA-DQB2 PPT2 C6orf25 DDX39B
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	NELFE DDX39B-AS1 C6orf47 MIR6721 MICB PRRC2A CYP21A2 SNORD48 LOC100287329 CLIC1 ATP6V1G2-DDX39B AIF1 SAPCD1 PBX2 ATP6V1G2 EHMT2 C2 TNF LTB VWA7 MIR4646 RNF5 NCR3 PRRT1 HCP5 NFKBIL1 LY6G6F FKBPL NOTCH4 LY6G6D MICA AGPAT1 ATF6B LY6G5C SLC44A4 HCG26 C6orf48 APOM CFB C4A HLA-DRA VARS AGER LST1 PPT2-EGFL8 HSPA1L LOC102725068 HSPA1B DDAH2 HSPA1A MSH5-SAPCD1 C2-AS1 TNXA MIR6832 SNORD117 NEU1 MSH5 LY6G6E EGFL8 HLA-B GPSM3 BAG6 ZBTB12 STK19 C4B SNORD84 LOC101929163 BTNL2 MIR1236 SNORD52 MIR6891 CSNK2B LY6G6C LTA MIR6833 TNXB LSM2 LY6G5B DXO HCG23 GPANK1 SKIV2L MCCD1 SNORA38 LOC100507547 CYP21A1P ABHD16A SAPCD1-AS1 C6orf10 PPT2 C6orf25 DDX39B
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	LY6G6F C6orf47 CSNK2B PRRC2A LY6G5B LY6G5C MIR6832 AIF1 GPANK1 LY6G6E APOM SNORA38 BAG6 MIR4646 ABHD16A
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	DDX39B-AS1 C6orf47 PRRC2A LOC100287329 MIR6832 ATP6V1G2-DDX39B AIF1 SNORD117 ATP6V1G2 TNF BAG6 LTB SNORD84 NCR3 NFKBIL1 CSNK2B LTA LY6G5B LY6G5C GPANK1 APOM MCCD1 SNORA38 LST1 ABHD16A DDX39B

More Information

Additional Information:

For this assay, SNP(s) [rs113947529] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding