Hs00436095_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20086120 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1	2	586	NP_001177255.1
	NM_022720.6	2	586	NP_073557.3
	AF165527.1	1	247	AAF82263.1
	AK313357.1	2	537
	BC009984.2	2	507	AAH09984.1
	BC078147.1	1	300	AAH78147.1
	BQ227899.1	2	543
	CR456356.1	1	244	CAG30242.1
	DA433651.1

Target Gene Details

• Entrez Gene ID: 100302197
• Gene Name: microRNA 1306
• Gene Aliases: MIRN1306, hsa-mir-1306, mir-1306
• Location: Chr.22:20086058-20086142 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MIR1306	NR_031706.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	TRMT2A MIR6816 LOC440792 RANBP1 MIR1286 DGCR8 CCDC188 RTN4R MIR3618 ZDHHC8 LOC284865 DGCR6L LINC00896 MIR1306
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	MIR185 LOC440792 RANBP1 TXNRD2 MIR1286 TANGO2 LINC00895 UFD1L ARVCF RTN4R MIR3618 CLDN5 CDC45 COMT C22orf29 MIR1306 LOC101927859 TRMT2A MIR6816 MIR4761 GNB1L TBX1 SEPT5-GP1BB GP1BB DGCR8 CCDC188 ZDHHC8 LOC284865 DGCR6L LINC00896 SEPT5
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	DGCR8 ARVCF MIR3618 ZDHHC8 MIR185 TRMT2A MIR6816 RANBP1 TANGO2 MIR1306
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	MIR185 LOC440792 RANBP1 TXNRD2 MIR1286 TANGO2 ARVCF RTN4R MIR3618 COMT C22orf29 MIR1306 TRMT2A MIR6816 MIR4761 GNB1L TBX1 SEPT5-GP1BB GP1BB DGCR8 CCDC188 ZDHHC8 LOC284865 DGCR6L LINC00896 SEPT5
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	MIR185 LOC440792 RANBP1 TXNRD2 MIR1286 TANGO2 ARVCF RTN4R MIR3618 COMT C22orf29 MIR1306 TRMT2A MIR6816 MIR4761 GNB1L TBX1 SEPT5-GP1BB GP1BB DGCR8 CCDC188 ZDHHC8 LOC284865 DGCR6L LINC00896 SEPT5
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	TRMT2A MIR6816 LOC440792 RANBP1 MIR1286 TANGO2 DGCR8 CCDC188 RTN4R MIR3618 ZDHHC8 LOC284865 DGCR6L LINC00896 MIR1306
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	DGCR8 CCDC188 RTN4R MIR3618 ZDHHC8 TRMT2A LOC284865 MIR6816 LINC00896 RANBP1 MIR1286 MIR1306
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	MIR185 TRMT2A MIR6816 LOC440792 RANBP1 MIR1286 TANGO2 DGCR8 CCDC188 RTN4R MIR3618 ZDHHC8 LOC284865 DGCR6L LINC00896 MIR1306
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	MIR185 TRMT2A MIR6816 LOC440792 MIR4761 RANBP1 TXNRD2 MIR1286 GNB1L TANGO2 TBX1 DGCR8 CCDC188 ARVCF RTN4R MIR3618 ZDHHC8 COMT LOC284865 DGCR6L LINC00896 C22orf29 MIR1306
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	DGCR8 CCDC188 MIR3618 ZDHHC8 MIR185 TRMT2A MIR6816 RANBP1 TANGO2 MIR1306
nsv953027	Chr.22:20085378 - 20303977 on Build GRCh38	Deletion	TRMT2A MIR6816 LOC440792 RANBP1 MIR1286 DGCR8 CCDC188 RTN4R MIR3618 ZDHHC8 LOC284865 LINC00896 MIR1306

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding