Hs00549460_cn

• Gene Symbol: ADORA2A
• Assay Reference Genome Location: Chr.22:24441819 on build GRCh38
• Cytoband: 22q11.23

Target Gene Details

• Entrez Gene ID: 135
• Gene Name: adenosine A2a receptor
• Gene Aliases: A2aR, ADORA2, RDC8
• Location: Chr.22:24423597-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A	NM_000675.5	3	2028	NP_000666.2
	NM_001278497.1	4	2199	NP_001265426.1
	NM_001278498.1	3	2093	NP_001265427.1
	NM_001278499.1	3	2008	NP_001265428.1
	NM_001278500.1	3	1875	NP_001265429.1
	NR_103543.1	2	1422
	NR_103544.1	2	1402
	AK123058.1	4	1938
	BC013780.1	3	1955	AAH13780.1
	CA307692.1	1	556
	HY249059.1	1	373
	M97370.1	2	1830	AAA58356.1

Target Gene Details

• Entrez Gene ID: 646023
• Gene Name: ADORA2A antisense RNA 1
• Gene Aliases: C22orf45
• Location: Chr.22:24429206-24495074 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A-AS1	NR_028483.2
	NR_028484.2
	DB449907.2

Target Gene Details

• Entrez Gene ID: 101730217
• Gene Name: SPECC1L-ADORA2A readthrough (NMD candidate)
• Gene Aliases: -
• Location: Chr.22:24270817-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPECC1L-ADORA2A	NR_103546.1	20	5748
	AB209022.1	20	5666	BAD92259.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2724068	Chr.22:24288741 - 24669870 on Build GRCh38	Deletion	ADORA2A-AS1 BCRP3 GUCD1 LRRC75B SNRPD3 GGT1 ADORA2A UPB1 SPECC1L POM121L10P SPECC1L-ADORA2A
dgv8039n54	Chr.22:23323169 - 24601506 on Build GRCh38	Gain	CES5AP1 ZDHHC8P1 RGL4 VPREB3 SNRPD3 LOC100652871 DRICH1 ADORA2A LOC388882 IGLL1 GGT5 SUSD2 C22orf15 GUSBP11 GUCD1 GGT1 SMARCB1 LOC107985555 MMP11 DDT LOC107985559 SPECC1L-ADORA2A ZNF70 GSTT2 ADORA2A-AS1 LOC101929374 SLC2A11 PCAT14 POM121L9P CABIN1 MIF MIF-AS1 LRRC75B CHCHD10 UPB1 SPECC1L DDTL DERL3 GSTT2B GSTTP1
nsv1057819	Chr.22:24290518 - 24624081 on Build GRCh38	Gain	ADORA2A-AS1 GUCD1 LRRC75B SNRPD3 GGT1 ADORA2A UPB1 SPECC1L SPECC1L-ADORA2A
nsv526567	Chr.22:23348138 - 24600663 on Build GRCh38	Gain	CES5AP1 ZDHHC8P1 RGL4 VPREB3 SNRPD3 LOC100652871 DRICH1 ADORA2A LOC388882 IGLL1 GGT5 SUSD2 C22orf15 GUSBP11 GUCD1 GGT1 SMARCB1 LOC107985555 MMP11 DDT LOC107985559 SPECC1L-ADORA2A ZNF70 GSTT2 ADORA2A-AS1 LOC101929374 SLC2A11 PCAT14 POM121L9P CABIN1 MIF MIF-AS1 LRRC75B CHCHD10 UPB1 SPECC1L DDTL DERL3 GSTT2B GSTTP1
esv2724041	Chr.22:23315914 - 24669376 on Build GRCh38	Deletion	CES5AP1 BCRP3 ZDHHC8P1 RGL4 VPREB3 SNRPD3 LOC100652871 DRICH1 ADORA2A LOC388882 IGLL1 GGT5 SUSD2 C22orf15 GUSBP11 GUCD1 GGT1 SMARCB1 LOC107985555 MMP11 DDT LOC107985559 SPECC1L-ADORA2A ZNF70 GSTT2 ADORA2A-AS1 BCR LOC101929374 SLC2A11 PCAT14 POM121L9P CABIN1 MIF MIF-AS1 LRRC75B CHCHD10 UPB1 SPECC1L DDTL DERL3 GSTT2B POM121L10P GSTTP1
nsv1055830	Chr.22:24005071 - 24643213 on Build GRCh38	Gain	ADORA2A-AS1 BCRP3 SNRPD3 ADORA2A POM121L9P GGT5 CABIN1 SUSD2 GUCD1 LRRC75B GGT1 UPB1 SPECC1L GSTTP1 SPECC1L-ADORA2A
esv3893463	Chr.22:24009046 - 24601506 on Build GRCh38	Gain	ADORA2A-AS1 SNRPD3 ADORA2A POM121L9P GGT5 CABIN1 SUSD2 GUCD1 LRRC75B GGT1 UPB1 SPECC1L SPECC1L-ADORA2A
dgv4528n100	Chr.22:23322244 - 24682765 on Build GRCh38	Gain	CES5AP1 BCRP3 ZDHHC8P1 RGL4 VPREB3 SNRPD3 LOC100652871 DRICH1 ADORA2A LOC388882 IGLL1 GGT5 SUSD2 C22orf15 GUSBP11 GUCD1 GGT1 SMARCB1 LOC107985555 MMP11 DDT LOC107985559 SPECC1L-ADORA2A ZNF70 GSTT2 ADORA2A-AS1 LOC101929374 SLC2A11 PCAT14 POM121L9P CABIN1 MIF MIF-AS1 LRRC75B CHCHD10 UPB1 SPECC1L DDTL DERL3 GSTT2B POM121L10P GSTTP1
nsv588744	Chr.22:24285587 - 24617379 on Build GRCh38	Gain	ADORA2A-AS1 GUCD1 LRRC75B SNRPD3 GGT1 ADORA2A UPB1 SPECC1L SPECC1L-ADORA2A
nsv9884	Chr.22:24415625 - 24662249 on Build GRCh38	Gain+Loss	ADORA2A-AS1 BCRP3 GUCD1 LRRC75B SNRPD3 GGT1 ADORA2A UPB1 SPECC1L POM121L10P SPECC1L-ADORA2A
esv3575443	Chr.22:23348201 - 24670505 on Build GRCh38	Gain	CES5AP1 BCRP3 ZDHHC8P1 RGL4 VPREB3 SNRPD3 LOC100652871 DRICH1 ADORA2A LOC388882 IGLL1 GGT5 SUSD2 C22orf15 GUSBP11 GUCD1 GGT1 SMARCB1 LOC107985555 MMP11 DDT LOC107985559 SPECC1L-ADORA2A ZNF70 GSTT2 ADORA2A-AS1 LOC101929374 SLC2A11 PCAT14 POM121L9P CABIN1 MIF MIF-AS1 LRRC75B CHCHD10 UPB1 SPECC1L DDTL DERL3 GSTT2B POM121L10P GSTTP1
nsv834160	Chr.22:24329972 - 24507687 on Build GRCh38	Gain	ADORA2A-AS1 ADORA2A UPB1 SPECC1L SPECC1L-ADORA2A

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

adenosine receptor signaling pathway
cAMP biosynthetic process
phagocytosis
apoptotic process
inflammatory response
cellular defense response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
central nervous system development
blood coagulation
sensory perception
blood circulation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
cellular protein metabolic process

Function(s)

G-protein coupled adenosine receptor activity
protein binding
enzyme binding
identical protein binding