Hs00569040_cn

• Gene Symbol: GRK6
• Assay Reference Genome Location: Chr.5:177441325 on build GRCh38
• Cytoband: 5q35.3

Target Gene Details

• Entrez Gene ID: 2870
• Gene Name: G protein-coupled receptor kinase 6
• Gene Aliases: GPRK6
• Location: Chr.5:177426496-177442849 on Build GRCh38
• Assay Gene Location: Overlaps Exon 17 - Intron 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GRK6	NM_001004105.2			NP_001004105.1
	NM_001004106.2			NP_001004106.1
	NM_002082.3			NP_002073.2
	XM_006714858.3			XP_006714921.1
	XM_006714859.2			XP_006714922.1
	XM_011534537.2			XP_011532839.1
	XM_011534538.1			XP_011532840.1
	AF040751.1			AAC09273.1
	AF040752.1			AAC09274.1
	AK056697.1
	BC009277.2			AAH09277.1
	BC017272.1			AAH17272.1
	L16862.1			AAA60175.1

Target Gene Details

• Entrez Gene ID: 340037
• Gene Name: PRR7 antisense RNA 1
• Gene Aliases: -
• Location: Chr.5:177437889-177447944 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRR7-AS1	NR_038915.1
	NR_038916.1
	BM083785.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv471057	Chr.5:177310308 - 177469411 on Build GRCh38	Loss	RGS14 MXD3 PFN3 GRK6 DBN1 F12 PRR7-AS1 PRR7 LMAN2 SLC34A1
nsv515805	Chr.5:177432847 - 177469411 on Build GRCh38	Loss	GRK6 DBN1 PRR7-AS1 PRR7
dgv10184n54	Chr.5:177357511 - 177469411 on Build GRCh38	Loss	RGS14 PFN3 GRK6 DBN1 F12 PRR7-AS1 PRR7 SLC34A1
nsv1161313	Chr.5:177356552 - 177463415 on Build GRCh38	Duplication	RGS14 PFN3 GRK6 DBN1 F12 PRR7-AS1 PRR7 SLC34A1
nsv1161311	Chr.5:177305104 - 177546474 on Build GRCh38	Duplication	RGS14 MXD3 F12 PRR7-AS1 PRR7 PDLIM7 DOK3 DDX41 PFN3 GRK6 DBN1 PRELID1 FAM193B LMAN2 SLC34A1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

desensitization of G-protein coupled receptor protein signaling pathway
protein phosphorylation
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of anion channel activity
Wnt signaling pathway

Function(s)

G-protein coupled receptor kinase activity
protein binding
ATP binding
beta-adrenergic receptor kinase activity