Hs00573357_cn

• Gene Symbol: FSTL3
• Assay Reference Genome Location: Chr.19:683075 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10272
• Gene Name: follistatin like 3
• Gene Aliases: FLRG, FSRP
• Location: Chr.19:676389-683392 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FSTL3	NM_005860.2	5	2194	NP_005851.1
	AL050194.1	1	70
	AY358917.1	5	2175	AAQ89276.1
	BC005839.2	5	2180	AAH05839.1
	BQ319646.1
	U76702.1	5	2166	AAC64321.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428360	Chr.19:232069 - 702131 on Build GRCh38	Gain	GZMM PLPP2 BSG RNF126 ODF3L2 HCN2 TPGS1 LOC101929060 FSTL3 C2CD4C CDC34 PRSS57 POLRMT MIER2 MADCAM1 SHC2 THEG FGF22
dgv134n111	Chr.19:607984 - 967584 on Build GRCh38	Deletion	CFD RNF126 MIR3187 LOC101928450 HCN2 RNU6-9 AZU1 FSTL3 PALM PTBP1 MIR4745 ARID3A KISS1R R3HDM4 MED16 PRSS57 POLRMT ELANE PRTN3 PLPPR3 MISP FGF22
nsv577978	Chr.19:294526 - 782854 on Build GRCh38	Gain	GZMM BSG RNF126 ODF3L2 LOC101928450 HCN2 TPGS1 LOC101929060 FSTL3 PALM C2CD4C CDC34 PRSS57 POLRMT MIER2 MADCAM1 SHC2 THEG MISP FGF22
nsv953938	Chr.19:355801 - 1104501 on Build GRCh38	Deletion	CFD RNF126 LOC101928450 TMEM259 RNU6-9 CNN2 PALM C2CD4C ABCA7 MIR4745 WDR18 ELANE THEG ARHGAP45 MISP GPX4 GZMM BSG ODF3L2 GRIN3B MIR3187 HCN2 TPGS1 AZU1 FSTL3 LOC105372235 POLR2E PTBP1 ARID3A KISS1R R3HDM4 CDC34 MED16 PRSS57 POLRMT RNU6-2 PRTN3 MADCAM1 SHC2 PLPPR3 FGF22
nsv470101	Chr.19:401714 - 1008505 on Build GRCh38	Loss	CFD RNF126 LOC101928450 RNU6-9 PALM C2CD4C MIR4745 WDR18 ELANE MISP GZMM BSG ODF3L2 GRIN3B MIR3187 HCN2 TPGS1 AZU1 FSTL3 LOC105372235 PTBP1 ARID3A KISS1R R3HDM4 CDC34 MED16 PRSS57 POLRMT PRTN3 MADCAM1 SHC2 PLPPR3 FGF22

More Information

Additional Information:

For this assay, SNP(s) [rs80087121] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

extracellular matrix glycoprotein

Gene Ontology Categories:

Process(es)

ossification
kidney development
hematopoietic progenitor cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
positive regulation of cell-cell adhesion
lung development
adrenal gland development
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to metal ion
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Function(s)

fibronectin binding
protein binding
activin binding