Hs00614900_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20085878 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1	2	344	NP_001177255.1
	NM_022720.6	2	344	NP_073557.3
	AF165527.1			AAF82263.1
	AK313357.1	2	295
	BC009984.2	2	265	AAH09984.1
	BC078147.1			AAH78147.1
	BQ227899.1	2	301
	CR456356.1			CAG30242.1
	DA433651.1	2	344

Target Gene Details

• Entrez Gene ID: 100500860
• Gene Name: microRNA 3618
• Gene Aliases: -
• Location: Chr.22:20085746-20085833 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MIR3618	NR_037412.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	DGCR6L RTN4R MIR1286 CCDC188 MIR1306 RANBP1 MIR6816 DGCR8 TRMT2A MIR3618 LOC284865 LINC00896 LOC440792 ZDHHC8
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	RTN4R MIR1306 UFD1L RANBP1 CLDN5 DGCR8 TBX1 LOC284865 TANGO2 LINC00896 COMT LOC440792 CDC45 ZDHHC8 DGCR6L MIR185 MIR1286 CCDC188 SEPT5 LINC00895 SEPT5-GP1BB MIR6816 TRMT2A MIR4761 MIR3618 LOC101927859 TXNRD2 ARVCF GNB1L GP1BB C22orf29
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	MIR185 MIR1306 TANGO2 RANBP1 MIR6816 DGCR8 TRMT2A ARVCF MIR3618 ZDHHC8
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	RTN4R MIR1306 RANBP1 DGCR8 TBX1 LOC284865 TANGO2 LINC00896 COMT LOC440792 ZDHHC8 DGCR6L MIR185 MIR1286 CCDC188 SEPT5 SEPT5-GP1BB MIR6816 TRMT2A MIR4761 MIR3618 TXNRD2 ARVCF GNB1L GP1BB C22orf29
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	RTN4R MIR1306 RANBP1 DGCR8 TBX1 LOC284865 TANGO2 LINC00896 COMT LOC440792 ZDHHC8 DGCR6L MIR185 MIR1286 CCDC188 SEPT5 SEPT5-GP1BB MIR6816 TRMT2A MIR4761 MIR3618 TXNRD2 ARVCF GNB1L GP1BB C22orf29
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	DGCR6L RTN4R MIR1286 CCDC188 MIR1306 RANBP1 MIR6816 DGCR8 TRMT2A MIR3618 LOC284865 TANGO2 LINC00896 LOC440792 ZDHHC8
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	LOC284865 RTN4R MIR1286 CCDC188 MIR1306 RANBP1 MIR6816 DGCR8 LINC00896 TRMT2A MIR3618 ZDHHC8
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	DGCR6L RTN4R MIR185 MIR1286 CCDC188 MIR1306 RANBP1 MIR6816 DGCR8 TRMT2A MIR3618 LOC284865 TANGO2 LINC00896 LOC440792 ZDHHC8
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	DGCR6L RTN4R MIR185 MIR1286 CCDC188 MIR1306 RANBP1 MIR6816 DGCR8 TRMT2A TBX1 MIR4761 MIR3618 LOC284865 TANGO2 LINC00896 COMT TXNRD2 ARVCF GNB1L LOC440792 ZDHHC8 C22orf29
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	MIR185 CCDC188 MIR1306 TANGO2 RANBP1 MIR6816 DGCR8 TRMT2A MIR3618 ZDHHC8
nsv953027	Chr.22:20085378 - 20303977 on Build GRCh38	Deletion	RTN4R MIR1286 CCDC188 MIR1306 RANBP1 MIR6816 DGCR8 TRMT2A MIR3618 LOC284865 LINC00896 LOC440792 ZDHHC8

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding