Hs00643112_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31656495 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NM_019101.2			NP_061974.2
	NR_045828.1
	XM_006715150.3			XP_006715213.1
	AA846749.1
	AF118393.3			AAD11443.2
	AF161454.1			AAF29014.1
	AJ245434.1			CAB51604.1
	BC020683.1			AAH20683.1
	BF344944.1
	BG564719.1
	CB054016.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_017011279.1			XP_016866768.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	LY6G6F TNF PPT2 LTB LOC102725068 TNXB ATP6V1G2-DDX39B EHMT2 SLC44A4 MIR6833 RNF5 LST1 LOC101929163 C4B HLA-DRB5 DDX39B PPT2-EGFL8 SNORD48 C6orf10 NFKBIL1 SNORD117 HSPA1A LTA HSPA1L SKIV2L LY6G5B APOM SAPCD1-AS1 LY6G5C LSM2 ATP6V1G2 NCR3 CFB HLA-DRB1 NELFE AGPAT1 MIR4646 C4A TNXA SNORA38 NOTCH4 SNORD52 EGFL8 STK19 AGER CYP21A1P LY6G6C PRRC2A DXO HLA-DRA HSPA1B LY6G6D DDX39B-AS1 DDAH2 CLIC1 HLA-DRB6 PBX2 AIF1 CYP21A2 C6orf47 VARS ABHD16A C6orf48 GPANK1 PRRT1 GPSM3 BTNL2 HCP5 MIR6721 SNORD84 C2 LOC100507547 MSH5-SAPCD1 MSH5 ZBTB12 ATF6B MIR6832 HCG26 HCG23 BAG6 CSNK2B VWA7 LOC100287329 FKBPL LY6G6E NEU1 SAPCD1 MCCD1 MIR1236 C2-AS1 C6orf25 MICB
nsv601942	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	APOM AIF1 C6orf47 PRRC2A MIR6832 BAG6 GPANK1 SNORA38
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	HLA-B LY6G6F TNF LTB LOC102725068 TNXB ATP6V1G2-DDX39B EHMT2 SLC44A4 LST1 C4B DDX39B MICA SNORD48 NFKBIL1 SNORD117 HSPA1A LTA HSPA1L SKIV2L LY6G5B APOM SAPCD1-AS1 LY6G5C LSM2 ATP6V1G2 NCR3 CFB NELFE MIR4646 C4A TNXA SNORA38 SNORD52 STK19 CYP21A1P LY6G6C PRRC2A DXO HSPA1B LY6G6D DDX39B-AS1 DDAH2 CLIC1 AIF1 CYP21A2 C6orf47 VARS ABHD16A C6orf48 GPANK1 MIR6891 HCP5 SNORD84 C2 MSH5-SAPCD1 MSH5 ZBTB12 MIR6832 HCG26 BAG6 CSNK2B VWA7 LOC100287329 LY6G6E NEU1 SAPCD1 MCCD1 MIR1236 C2-AS1 C6orf25 MICB
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	HLA-DPA1 LY6G6F DAXX TNF LTB LOC102725068 TNXB EHMT2 C4B HLA-DRB5 PPT2-EGFL8 NFKBIL1 HSPA1A LTA HSPA1L SKIV2L COL11A2 APOM SAPCD1-AS1 LSM2 MIR5004 PSMB9 ZBTB9 CFB HLA-DRB1 AGPAT1 MIR4646 C4A NOTCH4 EGFL8 STK19 CYP21A1P HLA-DOB PRRC2A HLA-DRA HSPA1B HLA-DQA1 DDX39B-AS1 DDAH2 MIR6873 MIR219A1 C6orf47 VARS ABHD16A HLA-DOA C6orf48 PRRT1 MIR6721 SNORD84 C2 HLA-DMB MSH5-SAPCD1 BRD2 MSH5 ZBTB12 ATF6B MIR6832 HCG26 BAG6 CSNK2B VWA7 RPS18 HLA-DPB2 LY6G6E SAPCD1 B3GALT4 HCG24 TAP2 ZBTB22 MICB HLA-DQB2 SYNGAP1 TAPBP PPT2 ATP6V1G2-DDX39B SLC44A4 MIR6833 RNF5 LST1 LOC100294145 PSMB8 RING1 PHF1 LOC101929163 DDX39B SNORD48 C6orf10 SNORD117 HLA-DMA PFDN6 LY6G5B LY6G5C ATP6V1G2 TAP1 RGL2 NCR3 KIFC1 NELFE TNXA SNORA38 HLA-DPB1 SNORD52 AGER LY6G6C MIR6834 DXO LY6G6D HSD17B8 CLIC1 HLA-DRB6 PBX2 AIF1 CYP21A2 MIR3135B PPP1R2P1 GPANK1 WDR46 GPSM3 BTNL2 HCP5 RXRB SLC39A7 HLA-DQB1-AS1 LOC100507547 CUTA HLA-DQA2 VPS52 HCG25 HCG23 HLA-DQB1 LOC100287329 FKBPL NEU1 MCCD1 MIR1236 PSMB8-AS1 C2-AS1 C6orf25
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	HLA-DPA1 LY6G6F DAXX TNF LTB LOC102725068 TNXB EHMT2 C4B HLA-DRB5 PPT2-EGFL8 NFKBIL1 HSPA1A LTA HSPA1L SKIV2L COL11A2 APOM SAPCD1-AS1 LSM2 MIR5004 PSMB9 ZBTB9 CFB HLA-DRB1 AGPAT1 MIR4646 C4A NOTCH4 EGFL8 STK19 CYP21A1P HLA-DOB PRRC2A HLA-DRA HSPA1B HLA-DQA1 DDX39B-AS1 DDAH2 MIR6873 MIR219A1 C6orf47 VARS ABHD16A HLA-DOA C6orf48 PRRT1 MIR6721 SNORD84 C2 HLA-DMB MSH5-SAPCD1 BRD2 MSH5 ZBTB12 ATF6B MIR6832 HCG26 BAG6 CSNK2B VWA7 RPS18 HLA-DPB2 LY6G6E SAPCD1 B3GALT4 HCG24 TAP2 ZBTB22 MICB HLA-DQB2 SYNGAP1 TAPBP PPT2 ATP6V1G2-DDX39B SLC44A4 MIR6833 RNF5 LST1 LOC100294145 PSMB8 RING1 PHF1 LOC101929163 DDX39B SNORD48 C6orf10 SNORD117 HLA-DMA PFDN6 LY6G5B LY6G5C ATP6V1G2 TAP1 RGL2 NCR3 KIFC1 NELFE TNXA SNORA38 HLA-DPB1 SNORD52 AGER LY6G6C MIR6834 DXO LY6G6D HSD17B8 CLIC1 HLA-DRB6 PBX2 AIF1 CYP21A2 MIR3135B PPP1R2P1 GPANK1 WDR46 GPSM3 BTNL2 HCP5 RXRB SLC39A7 HLA-DQB1-AS1 LOC100507547 CUTA HLA-DQA2 VPS52 HCG25 HCG23 HLA-DQB1 LOC100287329 FKBPL NEU1 MCCD1 MIR1236 PSMB8-AS1 C2-AS1 C6orf25
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	HLA-B LY6G6F TNF PPT2 LTB LOC102725068 TNXB ATP6V1G2-DDX39B EHMT2 SLC44A4 MIR6833 RNF5 LST1 LOC101929163 C4B DDX39B MICA PPT2-EGFL8 SNORD48 C6orf10 NFKBIL1 SNORD117 HSPA1A LTA HSPA1L SKIV2L LY6G5B APOM SAPCD1-AS1 LY6G5C LSM2 ATP6V1G2 NCR3 CFB NELFE AGPAT1 MIR4646 C4A TNXA SNORA38 NOTCH4 SNORD52 EGFL8 STK19 AGER CYP21A1P LY6G6C PRRC2A DXO HLA-DRA HSPA1B LY6G6D DDX39B-AS1 DDAH2 CLIC1 PBX2 AIF1 CYP21A2 C6orf47 VARS ABHD16A C6orf48 GPANK1 PRRT1 GPSM3 MIR6891 BTNL2 HCP5 MIR6721 SNORD84 C2 LOC100507547 MSH5-SAPCD1 MSH5 ZBTB12 ATF6B MIR6832 HCG26 HCG23 BAG6 CSNK2B VWA7 LOC100287329 FKBPL LY6G6E NEU1 SAPCD1 MCCD1 MIR1236 C2-AS1 C6orf25 MICB
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	APOM AIF1 LY6G5C LY6G6F C6orf47 ABHD16A MIR6832 BAG6 GPANK1 MIR4646 CSNK2B SNORA38 LY6G6E PRRC2A LY6G5B
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	AIF1 C6orf47 TNF ABHD16A LTB ATP6V1G2-DDX39B GPANK1 LST1 DDX39B NFKBIL1 SNORD117 LTA SNORD84 LY6G5B APOM LY6G5C ATP6V1G2 NCR3 MIR6832 BAG6 CSNK2B SNORA38 LOC100287329 PRRC2A MCCD1 DDX39B-AS1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding