Hs00657595_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4258250 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Overlaps Intron 8 - Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2			NP_003214.1
	XM_011522633.2			XP_011520935.1
	XM_011522635.2			XP_011520937.1
	AB209146.1			BAD92383.1
	BC010576.1			AAH10576.1
	BU159415.1
	CR541726.1			CAG46527.1
	S73885.1			AAB32235.1
	X57435.1			CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	EEF2KMT TFAP4 GLIS2 SEC14L5 NAGPA CDIP1 CORO7-PAM16 C16orf96 HMOX2 ALG1 GLIS2-AS1 PPL DNAJA3 UBN1 RBFOX1 UBALD1 MIR6769A SMIM22 GLYR1 C16orf89 MGRN1 C16orf71 ROGDI ADCY9 NUDT16L1 LOC105371063 VASN ANKS3 SEPT12 PAM16 NAGPA-AS1 ZNF500 CORO7 LINC01569 SRL NMRAL1
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	TFAP4 ADCY9 LINC01569 CREBBP LOC105371063 LOC102724927 SRL
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	TFAP4 GLIS2 CORO7 LINC01569 CORO7-PAM16 LOC105371063 VASN SRL PAM16 GLIS2-AS1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding