Hs00675626_cn

• Gene Symbol: GRB2
• Assay Reference Genome Location: Chr.17:75319385 on build GRCh38
• Cytoband: 17q25.1

Target Gene Details

• Entrez Gene ID: 2885
• Gene Name: growth factor receptor bound protein 2
• Gene Aliases: ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
• Location: Chr.17:75318076-75405709 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GRB2	NM_002086.4	6	1994	NP_002077.1
	NM_203506.2	5	1872	NP_987102.1
	BQ962129.1	1	402

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv111943	Chr.17:75316951 - 75319447 on Build GRCh38	Deletion	GRB2
nsv510727	Chr.17:75260216 - 75331456 on Build GRCh38	Deletion	GGA3 GRB2 LOC100287042 SLC25A19 MIF4GD MRPS7
nsv1066312	Chr.17:75260266 - 75323694 on Build GRCh38	Gain	GGA3 GRB2 LOC100287042 SLC25A19 MIF4GD MRPS7
nsv833541	Chr.17:75297204 - 75460023 on Build GRCh38	Loss	MIR3678 GRB2 TMEM94
nsv576027	Chr.17:75249939 - 75750289 on Build GRCh38	Gain	LLGL2 MIR3678 LOC100287042 CASKIN2 SMIM6 MRPS7 SAP30BP GGA3 GRB2 MIR6785 TMEM94 TSEN54 MYO15B SLC25A19 SMIM5 RECQL5 MIF4GD ITGB4

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

MAPK cascade
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
cell-cell signaling
axon guidance
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of signal transduction
regulation of phosphatidylinositol 3-kinase signaling
viral process
positive regulation of actin filament polymerization
T cell costimulation
receptor internalization
phosphatidylinositol-3-phosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
signal transduction in response to DNA damage
regulation of MAPK cascade
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
anatomical structure formation involved in morphogenesis
leukocyte migration
branching involved in labyrinthine layer morphogenesis
cellular response to ionizing radiation
positive regulation of reactive oxygen species metabolic process

Function(s)

SH3/SH2 adaptor activity
Ras guanyl-nucleotide exchange factor activity
epidermal growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
1-phosphatidylinositol-3-kinase activity
SH3 domain binding
protein kinase binding
protein phosphatase binding
identical protein binding
insulin receptor substrate binding
poly(A) RNA binding
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity