Hs00707808_cn

• Gene Symbol: FBXW7
• Assay Reference Genome Location: Chr.4:152324298 on build GRCh38
• Cytoband: 4q31.3

Target Gene Details

• Entrez Gene ID: 55294
• Gene Name: F-box and WD repeat domain containing 7
• Gene Aliases: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
• Location: Chr.4:152321258-152536095 on Build GRCh38
• Assay Gene Location: Within Exon 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FBXW7	NM_001013415.1	10	1564	NP_001013433.1
	NM_018315.4	10	1729	NP_060785.2
	NM_033632.3	11	1903	NP_361014.1
	XM_011532083.1	13	2916	XP_011530385.1
	XM_011532084.1	12	2866	XP_011530386.1
	XM_011532085.1	11	2773	XP_011530387.1
	XM_011532086.1	14	3094	XP_011530388.1
	XM_011532087.1	13	3044	XP_011530389.1
	XM_011532088.1	11	2302	XP_011530390.1
	XM_017008362.1	13	3313	XP_016863851.1
	AB209725.1	10	1493	BAD92962.1
	AF383178.1	10	1303	AAK60269.1
	AF411971.1	10	1816	AAL06290.1
	AF411972.1	10	1597	AAL06291.1
	AK001933.1	10	1354	BAA91986.1
	AK131383.1	2	2800
	AK223449.1	10	1531	BAD97169.1
	AK294568.1	9	1290
	AK299722.1	9	1312
	AK315142.1	10	1511
	AY008274.1	10	1566	AAG16640.1
	AY033553.1	10	1597	AAK57547.1
	AY049984.1	10	1810	AAL07271.1
	BC037320.2	10	1484	AAH37320.1
	BC117244.1	11	1871
	BC117246.1	11	1871
	BC143944.1	12	1921
	CR749305.1	11	2034	CAH18160.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv4553	Chr.4:152323453 - 152349980 on Build GRCh38	Insertion	FBXW7 DEAR
dgv5439n100	Chr.4:152321467 - 152364755 on Build GRCh38	Loss	FBXW7 DEAR
nsv1031970	Chr.4:152308716 - 152413464 on Build GRCh38	Gain	FBXW7 DEAR

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein polyubiquitination
vasculature development
sister chromatid cohesion
negative regulation of triglyceride biosynthetic process
regulation of lipid storage
viral process
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
negative regulation of DNA endoreduplication
regulation of protein localization
positive regulation of epidermal growth factor-activated receptor activity
negative regulation of Notch signaling pathway
protein stabilization
positive regulation of ubiquitin-protein transferase activity
lipid homeostasis
positive regulation of ERK1 and ERK2 cascade
positive regulation of proteasomal protein catabolic process
regulation of cell cycle G1/S phase transition
regulation of mitophagy
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of protein targeting to mitochondrion
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of hepatocyte proliferation
negative regulation of SREBP signaling pathway

Function(s)

ubiquitin-protein transferase activity
protein binding
cyclin binding
protein binding, bridging
ubiquitin protein ligase binding
identical protein binding
phosphothreonine binding
ubiquitin-protein transferase activator activity