Hs00870287_cn

• Gene Symbol: PAG1
• Assay Reference Genome Location: Chr.8:80970801 on build GRCh38
• Cytoband: 8q21.13

Target Gene Details

• Entrez Gene ID: 55824
• Gene Name: phosphoprotein membrane anchor with glycosphingolipid microdomains 1
• Gene Aliases: CBP, PAG
• Location: Chr.8:80967810-81112080 on Build GRCh38
• Assay Gene Location: Within Exon 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PAG1	NM_018440.3	9	7753	NP_060910.3
	XM_017013640.1	8	7706	XP_016869129.1
	XM_017013641.1	8	7305	XP_016869130.1
	XM_017013642.1	8	7318	XP_016869131.1
	XM_017013643.1	8	7294	XP_016869132.1
	AK095177.1	1	120

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv34101	Chr.8:80912902 - 80985211 on Build GRCh38	Loss	PAG1
nsv831367	Chr.8:80934819 - 81144000 on Build GRCh38	Gain	PAG1

More Information

Additional Information:

For this assay, SNP(s) [rs115415146] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

adaptive immune response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
positive regulation of signal transduction
intracellular signal transduction
T cell receptor signaling pathway
regulation of T cell activation
negative regulation of T cell activation

Function(s)

transmembrane receptor protein tyrosine kinase adaptor activity
SH3/SH2 adaptor activity
protein binding
SH2 domain binding