Hs00967861_cn

• Gene Symbol: FIS1
• Assay Reference Genome Location: Chr.7:101239843 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 51024
• Gene Name: fission, mitochondrial 1
• Gene Aliases: CGI-135, TTC11
• Location: Chr.7:101239612-101245090 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FIS1	NM_016068.2	5	508	NP_057152.2
	AF151893.1	5	503	AAD34130.1
	AK310968.1	4	662
	AK311665.1	5	776
	BC003540.1	5	486	AAH03540.1
	BC009428.1	5	486	AAH09428.1
	BI836529.1	5	508

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv5875	Chr.7:101227053 - 101259693 on Build GRCh38	Insertion	FIS1 CLDN15
nsv831077	Chr.7:101230928 - 101440649 on Build GRCh38	Loss	FIS1 LOC101927721 COL26A1 CLDN15 IFT22 LOC101927746
esv2422376	Chr.7:101100204 - 101373190 on Build GRCh38	Duplication	AP1S1 CLDN15 SERPINE1 NAT16 VGF MIR4653 FIS1 LOC101927721 MOGAT3 COL26A1 IFT22 LOC101927746 PLOD3 ZNHIT1
esv2422326	Chr.7:101190168 - 101356850 on Build GRCh38	Duplication	FIS1 LOC101927721 MOGAT3 CLDN15 IFT22 LOC101927746 PLOD3 ZNHIT1
nsv1030604	Chr.7:101074451 - 101580185 on Build GRCh38	Gain	LINC01007 AP1S1 CLDN15 SERPINE1 NAT16 VGF MIR4653 FIS1 TRIM56 LOC101927721 MOGAT3 COL26A1 IFT22 LOC101927746 PLOD3 ZNHIT1
esv2734888	Chr.7:99975623 - 101290285 on Build GRCh38	Deletion	MIR4658 CNPY4 ZASP ACTL6B C7orf43 STAG3L5P MUC17 PCOLCE TRIP6 LOC102724094 PPP1R35 ZSCAN21 AP4M1 FIS1 TAF6 MBLAC1 SPDYE3 COPS6 MUC3A FBXO24 UFSP1 STAG3L5P-PVRIG2P-PILRB MEPCE AP1S1 TFR2 GPC2 PVRIG2P SERPINE1 ZKSCAN1 VGF PMS2P1 ACHE PCOLCE-AS1 LRCH4 PILRA PVRIG SLC12A9 GIGYF1 AZGP1 GATS NYAP1 MIR106B CLDN15 POP7 EPO MCM7 MUC12 MIR4653 LOC105375429 MIR25 SAP25 MIR93 LAMTOR4 MOSPD3 MIR6875 GNB2 MIR6840 ZAN AGFG2 PILRB EPHB4 ZCWPW1 AZGP1P1 SRRT NAT16 STAG3 ZNF3 TRIM56 GAL3ST4 MOGAT3 TSC22D4 PLOD3 ZNHIT1 C7orf61
esv2752134	Chr.7:101156850 - 101498586 on Build GRCh38	Gain	AP1S1 CLDN15 NAT16 VGF MIR4653 FIS1 LOC101927721 MOGAT3 COL26A1 IFT22 LOC101927746 PLOD3 ZNHIT1
nsv607978	Chr.7:101217932 - 101328323 on Build GRCh38	Loss	FIS1 LOC101927721 CLDN15 IFT22 LOC101927746 ZNHIT1
nsv831075	Chr.7:101049016 - 101273737 on Build GRCh38	Loss	VGF AP1S1 MIR4653 FIS1 TRIM56 MOGAT3 MUC17 CLDN15 SERPINE1 NAT16 PLOD3 ZNHIT1
nsv607974	Chr.7:101149529 - 101328323 on Build GRCh38	Loss	VGF AP1S1 MIR4653 FIS1 LOC101927721 MOGAT3 CLDN15 IFT22 LOC101927746 NAT16 PLOD3 ZNHIT1
esv3614318	Chr.7:101206795 - 101265542 on Build GRCh38	Loss	FIS1 CLDN15 PLOD3 ZNHIT1
esv3614324	Chr.7:101231569 - 101248238 on Build GRCh38	Gain	FIS1 CLDN15
nsv831076	Chr.7:101185566 - 101368393 on Build GRCh38	Loss	FIS1 LOC101927721 MOGAT3 COL26A1 CLDN15 IFT22 LOC101927746 PLOD3 ZNHIT1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitochondrial fission
mitophagy
release of cytochrome c from mitochondria
protein targeting to mitochondrion
positive regulation of cytosolic calcium ion concentration
mitochondrial fusion
regulation of mitochondrion organization
peroxisome fission
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial fragmentation involved in apoptotic process
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
mitochondrion morphogenesis
positive regulation of mitochondrial fission
positive regulation of protein targeting to membrane
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

receptor binding
protein binding