Hs01065564_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96115404 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	842	NP_000673.2
	BC133021.1	1	842
	BC136537.1	1	842
	CV806541.1	1	287

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	SEMA4C STARD7 CIAO1 FAHD2CP MIR3127 CNNM3 ANKRD39 ANKRD36C TMEM127 LOC105373495 ADRA2B NCAPH DUSP2 LOC100506076 FAM178B KANSL3 FAHD2B ANKRD36 CNNM4 ITPRIPL1 LOC105373496 LOC107984110 ARID5A ANKRD36B SNRNP200 ANKRD23 LOC100506123 STARD7-AS1 LMAN2L LOC653924 LOC101927053 ASTL GPAT2 FER1L5 NEURL3
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	DUSP2 ASTL ADRA2B
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	SEMA4C STARD7 CIAO1 FAHD2CP MIR3127 CNNM3 ANKRD39 ANKRD36C TMEM127 LOC105373495 ADRA2B NCAPH DUSP2 LOC100506076 FAM178B KANSL3 FAHD2B ANKRD36 CNNM4 ITPRIPL1 LOC105373496 LOC107984110 ARID5A ANKRD36B SNRNP200 ANKRD23 LOC100506123 STARD7-AS1 LMAN2L LOC653924 LOC101927053 ASTL GPAT2 FER1L5 NEURL3
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	SEMA4C STARD7 CIAO1 FAHD2CP MIR3127 CNNM3 ANKRD39 ANKRD36C TMEM127 LOC105373495 ADRA2B NCAPH DUSP2 LOC100506076 FAM178B KANSL3 FAHD2B ANKRD36 CNNM4 ITPRIPL1 LOC105373496 LOC107984110 ARID5A ANKRD36B SNRNP200 ANKRD23 LOC100506123 STARD7-AS1 LMAN2L LOC653924 LOC101927053 ASTL GPAT2 FER1L5 NEURL3

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding