Hs01079780_cn

• Gene Symbol: PSMC3
• Assay Reference Genome Location: Chr.11:47420269 on build GRCh38
• Cytoband: 11p11.2

Target Gene Details

• Entrez Gene ID: 5702
• Gene Name: proteasome 26S subunit, ATPase 3
• Gene Aliases: TBP1
• Location: Chr.11:47418769-47426473 on Build GRCh38
• Assay Gene Location: Overlaps Intron 10 - Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PSMC3	NM_002804.4			NP_002795.2
	XM_017018026.1			XP_016873515.1
	AK222485.1			BAD96205.1
	AK291896.1
	AK313518.1
	BC008713.2
	BC073165.1
	BC106920.2			AAI06921.1
	BC107804.1			AAI07805.1
	CR456731.1			CAG33012.1
	M34079.1			AAA36666.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv832141	Chr.11:47311629 - 47499441 on Build GRCh38	Loss	CELF1 SPI1 PSMC3 MADD RAPSN MIR4487 MYBPC3 SLC39A13
nsv554210	Chr.11:47359042 - 47427993 on Build GRCh38	Loss	SPI1 PSMC3 MIR4487 SLC39A13
nsv825871	Chr.11:47354469 - 47435986 on Build GRCh38	Gain	SPI1 PSMC3 MIR4487 SLC39A13

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

MAPK cascade
protein polyubiquitination
blastocyst development
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
viral process
ER-associated ubiquitin-dependent protein catabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of proteasomal protein catabolic process
negative regulation of nucleic acid-templated transcription

Function(s)

transcription coactivator activity
transcription corepressor activity
protein binding
ATP binding
ATPase activity
TBP-class protein binding
proteasome-activating ATPase activity