Hs01089241_cn

• Gene Symbol: FSTL3
• Assay Reference Genome Location: Chr.19:682077 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10272
• Gene Name: follistatin like 3
• Gene Aliases: FLRG, FSRP
• Location: Chr.19:676389-683392 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FSTL3	NM_005860.2	5	1196	NP_005851.1
	AK291958.1
	AK311566.1	3	821
	AY358917.1	5	1177	AAQ89276.1
	BC005839.2	5	1182	AAH05839.1
	U76702.1	5	1168	AAC64321.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428360	Chr.19:232069 - 702131 on Build GRCh38	Gain	SHC2 PLPP2 HCN2 CDC34 BSG FSTL3 THEG ODF3L2 RNF126 POLRMT MADCAM1 FGF22 GZMM TPGS1 PRSS57 MIER2 LOC101929060 C2CD4C
dgv134n111	Chr.19:607984 - 967584 on Build GRCh38	Deletion	MIR3187 PRTN3 MISP HCN2 FSTL3 RNF126 CFD POLRMT AZU1 MED16 FGF22 ARID3A RNU6-9 ELANE PTBP1 PRSS57 KISS1R PLPPR3 R3HDM4 MIR4745 LOC101928450 PALM
nsv577978	Chr.19:294526 - 782854 on Build GRCh38	Gain	SHC2 MISP HCN2 CDC34 BSG FSTL3 THEG ODF3L2 RNF126 POLRMT MADCAM1 FGF22 GZMM TPGS1 PRSS57 MIER2 LOC101928450 LOC101929060 PALM C2CD4C
nsv953938	Chr.19:355801 - 1104501 on Build GRCh38	Deletion	LOC105372235 PRTN3 MISP GRIN3B HCN2 GPX4 ODF3L2 WDR18 CFD AZU1 POLR2E MADCAM1 TPGS1 RNU6-9 ELANE PTBP1 ABCA7 R3HDM4 MIR4745 PALM C2CD4C SHC2 MIR3187 ARHGAP45 CNN2 CDC34 BSG FSTL3 THEG RNF126 POLRMT MED16 FGF22 ARID3A GZMM TMEM259 PRSS57 KISS1R RNU6-2 PLPPR3 LOC101928450
nsv470101	Chr.19:401714 - 1008505 on Build GRCh38	Loss	LOC105372235 PRTN3 MISP GRIN3B HCN2 ODF3L2 WDR18 CFD AZU1 MADCAM1 TPGS1 RNU6-9 ELANE PTBP1 R3HDM4 MIR4745 PALM C2CD4C SHC2 MIR3187 CDC34 BSG FSTL3 RNF126 POLRMT MED16 FGF22 ARID3A GZMM PRSS57 KISS1R PLPPR3 LOC101928450

More Information

Additional Information:

For this assay, SNP(s) [rs72976224] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

extracellular matrix glycoprotein

Gene Ontology Categories:

Process(es)

ossification
kidney development
hematopoietic progenitor cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
positive regulation of cell-cell adhesion
lung development
adrenal gland development
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to metal ion
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Function(s)

fibronectin binding
protein binding
activin binding