Hs01120639_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4272719 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2	1	282	NP_003214.1
	AK309301.1	1	357
	BC010576.1	1	171	AAH10576.1
	BU159415.1	1	235
	CR541726.1			CAG46527.1
	DA449763.1	1	357
	S73885.1	1	288	AAB32235.1
	X57435.1			CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv827529	Chr.16:4272318 - 4274247 on Build GRCh38	Gain	TFAP4
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	LOC105371063 PAM16 HMOX2 DNAJA3 CDIP1 VASN TFAP4 ZNF500 MIR6769A GLYR1 NAGPA ALG1 SEPT12 CORO7 CORO7-PAM16 ANKS3 LINC01569 NAGPA-AS1 RBFOX1 C16orf71 GLIS2 SMIM22 C16orf96 MGRN1 ROGDI EEF2KMT SEC14L5 C16orf89 NUDT16L1 UBN1 NMRAL1 SRL GLIS2-AS1 UBALD1 ADCY9 PPL
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	LOC105371063 PAM16 GLIS2 SRL GLIS2-AS1 VASN TFAP4 CORO7 CORO7-PAM16 LINC01569
dgv1290n106	Chr.16:4272599 - 4273399 on Build GRCh38	Deletion	TFAP4
nsv1070316	Chr.16:4272598 - 4273299 on Build GRCh38	Deletion	TFAP4

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding