Hs01199234_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96114290 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	1956	NP_000673.2
	BC133021.1	1	1956
	BC136537.1	1	1956
	BF475329.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	STARD7 NEURL3 KANSL3 LOC100506076 ADRA2B FAHD2CP SNRNP200 ANKRD36B FAHD2B ARID5A CNNM4 ANKRD36C LOC105373496 LMAN2L SEMA4C DUSP2 ASTL FER1L5 NCAPH ANKRD23 GPAT2 LOC107984110 MIR3127 LOC105373495 TMEM127 FAM178B ANKRD36 LOC653924 LOC100506123 LOC101927053 ITPRIPL1 CIAO1 CNNM3 STARD7-AS1 ANKRD39
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	ADRA2B DUSP2 ASTL
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	STARD7 NEURL3 KANSL3 LOC100506076 ADRA2B FAHD2CP SNRNP200 ANKRD36B FAHD2B ARID5A CNNM4 ANKRD36C LOC105373496 LMAN2L SEMA4C DUSP2 ASTL FER1L5 NCAPH ANKRD23 GPAT2 LOC107984110 MIR3127 LOC105373495 TMEM127 FAM178B ANKRD36 LOC653924 LOC100506123 LOC101927053 ITPRIPL1 CIAO1 CNNM3 STARD7-AS1 ANKRD39
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	STARD7 NEURL3 KANSL3 LOC100506076 ADRA2B FAHD2CP SNRNP200 ANKRD36B FAHD2B ARID5A CNNM4 ANKRD36C LOC105373496 LMAN2L SEMA4C DUSP2 ASTL FER1L5 NCAPH ANKRD23 GPAT2 LOC107984110 MIR3127 LOC105373495 TMEM127 FAM178B ANKRD36 LOC653924 LOC100506123 LOC101927053 ITPRIPL1 CIAO1 CNNM3 STARD7-AS1 ANKRD39

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding