Hs01216366_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4262402 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Overlaps Intron 4 - Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2			NP_003214.1
	XM_011522633.2			XP_011520935.1
	XM_011522635.2			XP_011520937.1
	AB209146.1			BAD92383.1
	AK309301.1
	BC010576.1			AAH10576.1
	BU159415.1
	CR541726.1			CAG46527.1
	S73885.1			AAB32235.1
	X57435.1			CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	UBN1 VASN NUDT16L1 ALG1 ZNF500 TFAP4 C16orf89 PAM16 ADCY9 NAGPA-AS1 RBFOX1 LOC105371063 NMRAL1 ANKS3 HMOX2 C16orf96 SRL GLIS2-AS1 CORO7 DNAJA3 CORO7-PAM16 CDIP1 UBALD1 GLIS2 EEF2KMT GLYR1 SMIM22 MGRN1 SEPT12 LINC01569 SEC14L5 ROGDI NAGPA PPL MIR6769A C16orf71
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	ADCY9 LOC102724927 LOC105371063 LINC01569 TFAP4 SRL CREBBP
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	GLIS2-AS1 CORO7 LOC105371063 CORO7-PAM16 VASN LINC01569 TFAP4 PAM16 GLIS2 SRL

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding