Hs01217392_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31657317 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Overlaps Exon 4 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NM_019101.2			NP_061974.2
	NR_045828.1
	XM_006715150.3			XP_006715213.1
	AA846749.1
	AF118393.3			AAD11443.2
	AF161454.1			AAF29014.1
	AJ245434.1			CAB51604.1
	BC020683.1			AAH20683.1
	BF344944.1
	BG564719.1
	CB054016.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_017011279.1			XP_016866768.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	ATP6V1G2 LOC100507547 DDX39B-AS1 ABHD16A SNORD52 CSNK2B PRRC2A NCR3 GPSM3 DDX39B AGPAT1 LY6G5C TNF VARS LY6G6F MIR1236 MCCD1 LOC102725068 C6orf10 LTB NELFE MICB HLA-DRA NEU1 LTA HLA-DRB1 C6orf25 SLC44A4 LY6G5B TNXA NOTCH4 HLA-DRB5 PRRT1 HCP5 AGER C2 DXO ATF6B DDAH2 CLIC1 GPANK1 VWA7 HCG26 LY6G6E C4B SKIV2L CYP21A2 MSH5 ZBTB12 SAPCD1-AS1 RNF5 TNXB C6orf48 HSPA1L C6orf47 SNORA38 BTNL2 LSM2 MIR4646 HSPA1B ATP6V1G2-DDX39B MIR6833 HCG23 NFKBIL1 AIF1 SNORD84 SNORD117 APOM CFB LOC100287329 HLA-DRB6 BAG6 SAPCD1 LY6G6D HSPA1A STK19 PPT2 C2-AS1 SNORD48 FKBPL LY6G6C PBX2 MIR6832 LST1 EGFL8 PPT2-EGFL8 LOC101929163 EHMT2 CYP21A1P C4A MIR6721 MSH5-SAPCD1
nsv601942	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	BAG6 MIR6832 GPANK1 AIF1 PRRC2A APOM C6orf47 SNORA38
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	ATP6V1G2 DDX39B-AS1 ABHD16A SNORD52 CSNK2B PRRC2A NCR3 DDX39B LY6G5C TNF VARS LY6G6F MIR1236 MCCD1 LOC102725068 LTB NELFE MICB NEU1 LTA C6orf25 SLC44A4 LY6G5B TNXA HCP5 C2 DXO DDAH2 CLIC1 GPANK1 VWA7 HCG26 LY6G6E C4B SKIV2L CYP21A2 MSH5 ZBTB12 SAPCD1-AS1 TNXB C6orf48 HSPA1L C6orf47 SNORA38 LSM2 MIR4646 HSPA1B ATP6V1G2-DDX39B NFKBIL1 AIF1 SNORD84 SNORD117 APOM CFB LOC100287329 MIR6891 BAG6 SAPCD1 LY6G6D MICA HSPA1A STK19 C2-AS1 SNORD48 LY6G6C MIR6832 LST1 EHMT2 CYP21A1P HLA-B C4A MSH5-SAPCD1
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	ATP6V1G2 HLA-DPB2 LOC100507547 SNORD52 CSNK2B PSMB8 GPSM3 TAP1 TNF HSD17B8 LY6G6F MIR1236 MCCD1 LOC102725068 C6orf10 LTB NELFE MICB HLA-DRA PHF1 NEU1 MIR3135B TAP2 HLA-DRB1 SLC44A4 HLA-DRB5 PRRT1 CUTA AGER C2 DXO SYNGAP1 DDAH2 GPANK1 VWA7 HLA-DOB HCG26 PFDN6 LY6G6E C4B CYP21A2 MSH5 RING1 ZBTB12 HLA-DMA RNF5 C6orf48 HSPA1L BTNL2 LSM2 HSPA1B ATP6V1G2-DDX39B HLA-DPB1 NFKBIL1 APOM CFB HLA-DRB6 DAXX B3GALT4 SLC39A7 MIR219A1 COL11A2 ZBTB22 LY6G6D VPS52 PPT2 C2-AS1 SNORD48 PPP1R2P1 WDR46 HLA-DOA LST1 PPT2-EGFL8 CYP21A1P C4A HLA-DQA2 DDX39B-AS1 ABHD16A HLA-DQB1-AS1 PRRC2A NCR3 DDX39B AGPAT1 LY6G5C VARS MIR6834 HCG25 LTA RXRB PSMB8-AS1 C6orf25 HLA-DPA1 LY6G5B TNXA NOTCH4 MIR5004 HCP5 ATF6B PSMB9 LOC100294145 CLIC1 RGL2 MIR6873 SKIV2L HLA-DMB SAPCD1-AS1 TNXB C6orf47 SNORA38 MIR4646 MIR6833 HLA-DQB1 HCG23 AIF1 SNORD84 SNORD117 LOC100287329 HCG24 BAG6 SAPCD1 RPS18 BRD2 HLA-DQB2 TAPBP HSPA1A HLA-DQA1 STK19 FKBPL LY6G6C PBX2 MIR6832 ZBTB9 EGFL8 LOC101929163 EHMT2 KIFC1 MIR6721 MSH5-SAPCD1
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	ATP6V1G2 HLA-DPB2 LOC100507547 SNORD52 CSNK2B PSMB8 GPSM3 TAP1 TNF HSD17B8 LY6G6F MIR1236 MCCD1 LOC102725068 C6orf10 LTB NELFE MICB HLA-DRA PHF1 NEU1 MIR3135B TAP2 HLA-DRB1 SLC44A4 HLA-DRB5 PRRT1 CUTA AGER C2 DXO SYNGAP1 DDAH2 GPANK1 VWA7 HLA-DOB HCG26 PFDN6 LY6G6E C4B CYP21A2 MSH5 RING1 ZBTB12 HLA-DMA RNF5 C6orf48 HSPA1L BTNL2 LSM2 HSPA1B ATP6V1G2-DDX39B HLA-DPB1 NFKBIL1 APOM CFB HLA-DRB6 DAXX B3GALT4 SLC39A7 MIR219A1 COL11A2 ZBTB22 LY6G6D VPS52 PPT2 C2-AS1 SNORD48 PPP1R2P1 WDR46 HLA-DOA LST1 PPT2-EGFL8 CYP21A1P C4A HLA-DQA2 DDX39B-AS1 ABHD16A HLA-DQB1-AS1 PRRC2A NCR3 DDX39B AGPAT1 LY6G5C VARS MIR6834 HCG25 LTA RXRB PSMB8-AS1 C6orf25 HLA-DPA1 LY6G5B TNXA NOTCH4 MIR5004 HCP5 ATF6B PSMB9 LOC100294145 CLIC1 RGL2 MIR6873 SKIV2L HLA-DMB SAPCD1-AS1 TNXB C6orf47 SNORA38 MIR4646 MIR6833 HLA-DQB1 HCG23 AIF1 SNORD84 SNORD117 LOC100287329 HCG24 BAG6 SAPCD1 RPS18 BRD2 HLA-DQB2 TAPBP HSPA1A HLA-DQA1 STK19 FKBPL LY6G6C PBX2 MIR6832 ZBTB9 EGFL8 LOC101929163 EHMT2 KIFC1 MIR6721 MSH5-SAPCD1
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	ATP6V1G2 LOC100507547 DDX39B-AS1 ABHD16A SNORD52 CSNK2B PRRC2A NCR3 GPSM3 DDX39B AGPAT1 LY6G5C TNF VARS LY6G6F MIR1236 MCCD1 LOC102725068 C6orf10 LTB NELFE MICB HLA-DRA NEU1 LTA C6orf25 SLC44A4 LY6G5B TNXA NOTCH4 PRRT1 HCP5 AGER C2 DXO ATF6B DDAH2 CLIC1 GPANK1 VWA7 HCG26 LY6G6E C4B SKIV2L CYP21A2 MSH5 ZBTB12 SAPCD1-AS1 RNF5 TNXB C6orf48 HSPA1L C6orf47 SNORA38 BTNL2 LSM2 MIR4646 HSPA1B ATP6V1G2-DDX39B MIR6833 HCG23 NFKBIL1 AIF1 SNORD84 SNORD117 APOM CFB LOC100287329 MIR6891 BAG6 SAPCD1 LY6G6D MICA HSPA1A STK19 PPT2 C2-AS1 SNORD48 FKBPL LY6G6C PBX2 MIR6832 LST1 EGFL8 PPT2-EGFL8 LOC101929163 EHMT2 CYP21A1P HLA-B C4A MIR6721 MSH5-SAPCD1
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	BAG6 LY6G5B ABHD16A CSNK2B PRRC2A C6orf47 SNORA38 LY6G5C MIR4646 LY6G6F MIR6832 GPANK1 AIF1 APOM LY6G6E
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	ATP6V1G2 DDX39B-AS1 ABHD16A CSNK2B PRRC2A NCR3 C6orf47 SNORA38 DDX39B LY6G5C TNF ATP6V1G2-DDX39B MCCD1 NFKBIL1 AIF1 SNORD84 SNORD117 LTB APOM LOC100287329 LTA BAG6 LY6G5B MIR6832 GPANK1 LST1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding