Hs01217392_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31657317 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Overlaps Exon 4 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NM_019101.2			NP_061974.2
	NR_045828.1
	XM_006715150.3			XP_006715213.1
	AA846749.1
	AF118393.3			AAD11443.2
	AF161454.1			AAF29014.1
	AJ245434.1			CAB51604.1
	BC020683.1			AAH20683.1
	BF344944.1
	BG564719.1
	CB054016.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_017011279.1			XP_016866768.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv462871	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	AIF1 SNORA38 APOM BAG6 MIR6832 GPANK1 PRRC2A C6orf47
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	MIR6833 BAG6 LTA ABHD16A SKIV2L HLA-DRA C2-AS1 C6orf48 PRRT1 LOC101929163 ZBTB12 C6orf10 HSPA1A TNF MSH5-SAPCD1 LY6G6C LY6G6D SNORD52 CYP21A2 C4B LST1 MSH5 SNORD117 NFKBIL1 HSPA1B DDX39B TNXB MIR1236 NOTCH4 SNORD84 SAPCD1 SLC44A4 CFB FKBPL TNXA CYP21A1P MIR4646 LY6G5B LY6G6F SNORD48 VARS CLIC1 NCR3 AGER GPSM3 LY6G6E DDX39B-AS1 LOC100507547 LY6G5C APOM LTB C2 HCG26 VWA7 STK19 C6orf25 PRRC2A PBX2 BTNL2 MIR6832 LSM2 MIR6721 HLA-DRB5 C6orf47 DDAH2 ATF6B MICB ATP6V1G2 NELFE MCCD1 PPT2-EGFL8 DXO EHMT2 PPT2 HLA-DRB6 AIF1 SNORA38 LOC102725068 SAPCD1-AS1 HSPA1L C4A HCG23 NEU1 ATP6V1G2-DDX39B EGFL8 AGPAT1 LOC100287329 HCP5 GPANK1 RNF5 HLA-DRB1 CSNK2B
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	MIR6833 HLA-DMA ABHD16A HLA-DQB1 C2-AS1 C6orf48 PRRT1 C6orf10 RXRB HSPA1A HLA-DPB1 LY6G6C C4B HLA-DQA2 LOC100294145 HLA-DPA1 MIR1236 MIR5004 PSMB8 HLA-DQB2 SNORD84 FKBPL CYP21A1P MIR4646 HLA-DMB DAXX VARS AGER GPSM3 DDX39B-AS1 HLA-DQB1-AS1 LOC100507547 LY6G5C LTB C2 HLA-DOA MIR219A1 PRRC2A PSMB8-AS1 PBX2 TAPBP B3GALT4 BTNL2 MIR6832 HSD17B8 LSM2 RING1 PHF1 HCG24 VPS52 MIR6721 HLA-DRB5 PSMB9 C6orf47 HLA-DQA1 HLA-DOB ATF6B RPS18 ATP6V1G2 NELFE MCCD1 ZBTB22 DXO EHMT2 RGL2 LOC102725068 HSPA1L C4A EGFL8 LOC100287329 HCP5 GPANK1 HLA-DRB1 CSNK2B BAG6 LTA SKIV2L HLA-DRA MIR6834 CUTA LOC101929163 ZBTB12 TNF HCG25 MSH5-SAPCD1 LY6G6D SNORD52 CYP21A2 ZBTB9 LST1 SLC39A7 TAP1 HLA-DPB2 MSH5 SNORD117 NFKBIL1 HSPA1B DDX39B TNXB MIR3135B SYNGAP1 NOTCH4 MIR6873 SAPCD1 SLC44A4 CFB TNXA LY6G5B LY6G6F SNORD48 CLIC1 NCR3 PFDN6 LY6G6E APOM KIFC1 PPP1R2P1 HCG26 VWA7 STK19 C6orf25 TAP2 BRD2 WDR46 COL11A2 DDAH2 MICB PPT2-EGFL8 PPT2 HLA-DRB6 AIF1 SNORA38 SAPCD1-AS1 HCG23 NEU1 ATP6V1G2-DDX39B AGPAT1 RNF5
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	HLA-B BAG6 LTA ABHD16A SKIV2L C2-AS1 C6orf48 MICA ZBTB12 HSPA1A TNF MSH5-SAPCD1 LY6G6C LY6G6D SNORD52 CYP21A2 C4B LST1 MSH5 SNORD117 NFKBIL1 HSPA1B DDX39B TNXB MIR6891 MIR1236 SNORD84 SAPCD1 SLC44A4 CFB TNXA CYP21A1P MIR4646 LY6G5B LY6G6F SNORD48 VARS CLIC1 NCR3 LY6G6E DDX39B-AS1 LY6G5C APOM LTB C2 HCG26 VWA7 STK19 C6orf25 PRRC2A MIR6832 LSM2 C6orf47 DDAH2 MICB ATP6V1G2 NELFE MCCD1 DXO EHMT2 AIF1 SNORA38 LOC102725068 SAPCD1-AS1 HSPA1L C4A NEU1 ATP6V1G2-DDX39B LOC100287329 HCP5 GPANK1 CSNK2B
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	MIR6833 HLA-DMA ABHD16A HLA-DQB1 C2-AS1 C6orf48 PRRT1 C6orf10 RXRB HSPA1A HLA-DPB1 LY6G6C C4B HLA-DQA2 LOC100294145 HLA-DPA1 MIR1236 MIR5004 PSMB8 HLA-DQB2 SNORD84 FKBPL CYP21A1P MIR4646 HLA-DMB DAXX VARS AGER GPSM3 DDX39B-AS1 HLA-DQB1-AS1 LOC100507547 LY6G5C LTB C2 HLA-DOA MIR219A1 PRRC2A PSMB8-AS1 PBX2 TAPBP B3GALT4 BTNL2 MIR6832 HSD17B8 LSM2 RING1 PHF1 HCG24 VPS52 MIR6721 HLA-DRB5 PSMB9 C6orf47 HLA-DQA1 HLA-DOB ATF6B RPS18 ATP6V1G2 NELFE MCCD1 ZBTB22 DXO EHMT2 RGL2 LOC102725068 HSPA1L C4A EGFL8 LOC100287329 HCP5 GPANK1 HLA-DRB1 CSNK2B BAG6 LTA SKIV2L HLA-DRA MIR6834 CUTA LOC101929163 ZBTB12 TNF HCG25 MSH5-SAPCD1 LY6G6D SNORD52 CYP21A2 ZBTB9 LST1 SLC39A7 TAP1 HLA-DPB2 MSH5 SNORD117 NFKBIL1 HSPA1B DDX39B TNXB MIR3135B SYNGAP1 NOTCH4 MIR6873 SAPCD1 SLC44A4 CFB TNXA LY6G5B LY6G6F SNORD48 CLIC1 NCR3 PFDN6 LY6G6E APOM KIFC1 PPP1R2P1 HCG26 VWA7 STK19 C6orf25 TAP2 BRD2 WDR46 COL11A2 DDAH2 MICB PPT2-EGFL8 PPT2 HLA-DRB6 AIF1 SNORA38 SAPCD1-AS1 HCG23 NEU1 ATP6V1G2-DDX39B AGPAT1 RNF5
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	MIR6833 HLA-B BAG6 LTA ABHD16A SKIV2L HLA-DRA C2-AS1 C6orf48 PRRT1 MICA LOC101929163 ZBTB12 C6orf10 HSPA1A TNF MSH5-SAPCD1 LY6G6C LY6G6D SNORD52 CYP21A2 C4B LST1 MSH5 SNORD117 NFKBIL1 HSPA1B DDX39B TNXB MIR6891 MIR1236 NOTCH4 SNORD84 SAPCD1 SLC44A4 CFB FKBPL TNXA CYP21A1P MIR4646 LY6G5B LY6G6F SNORD48 VARS CLIC1 NCR3 AGER GPSM3 LY6G6E DDX39B-AS1 LOC100507547 LY6G5C APOM LTB C2 HCG26 VWA7 STK19 C6orf25 PRRC2A PBX2 BTNL2 MIR6832 LSM2 MIR6721 C6orf47 DDAH2 ATF6B MICB ATP6V1G2 NELFE MCCD1 PPT2-EGFL8 DXO EHMT2 PPT2 AIF1 SNORA38 LOC102725068 SAPCD1-AS1 HSPA1L C4A HCG23 NEU1 ATP6V1G2-DDX39B EGFL8 AGPAT1 LOC100287329 HCP5 GPANK1 RNF5 CSNK2B
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	LY6G6E LY6G5C APOM BAG6 ABHD16A PRRC2A AIF1 SNORA38 MIR6832 MIR4646 LY6G5B LY6G6F GPANK1 CSNK2B C6orf47
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	DDX39B-AS1 LY6G5C APOM LTB BAG6 LTA ABHD16A PRRC2A MIR6832 TNF LST1 C6orf47 SNORD117 NFKBIL1 ATP6V1G2 DDX39B MCCD1 SNORD84 AIF1 SNORA38 LY6G5B ATP6V1G2-DDX39B LOC100287329 NCR3 GPANK1 CSNK2B

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding