Hs01559566_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96116086 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	160	NP_000673.2
	BC133021.1	1	160
	BC136537.1	1	160

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	LOC100506123 STARD7-AS1 DUSP2 ITPRIPL1 SNRNP200 ARID5A ADRA2B STARD7 CNNM3 NEURL3 ANKRD39 KANSL3 GPAT2 CNNM4 FAM178B LOC100506076 ANKRD36C ANKRD36 FER1L5 LOC105373495 FAHD2B LOC101927053 MIR3127 ASTL LOC105373496 SEMA4C ANKRD36B FAHD2CP CIAO1 TMEM127 LMAN2L LOC107984110 ANKRD23 NCAPH LOC653924
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	DUSP2 ASTL ADRA2B
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	LOC100506123 STARD7-AS1 DUSP2 ITPRIPL1 SNRNP200 ARID5A ADRA2B STARD7 CNNM3 NEURL3 ANKRD39 KANSL3 GPAT2 CNNM4 FAM178B LOC100506076 ANKRD36C ANKRD36 FER1L5 LOC105373495 FAHD2B LOC101927053 MIR3127 ASTL LOC105373496 SEMA4C ANKRD36B FAHD2CP CIAO1 TMEM127 LMAN2L LOC107984110 ANKRD23 NCAPH LOC653924
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	LOC100506123 STARD7-AS1 DUSP2 ITPRIPL1 SNRNP200 ARID5A ADRA2B STARD7 CNNM3 NEURL3 ANKRD39 KANSL3 GPAT2 CNNM4 FAM178B LOC100506076 ANKRD36C ANKRD36 FER1L5 LOC105373495 FAHD2B LOC101927053 MIR3127 ASTL LOC105373496 SEMA4C ANKRD36B FAHD2CP CIAO1 TMEM127 LMAN2L LOC107984110 ANKRD23 NCAPH LOC653924

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding