Hs01586713_cn

• Gene Symbol: ADORA2A
• Assay Reference Genome Location: Chr.22:24440943 on build GRCh38
• Cytoband: 22q11.23

Target Gene Details

• Entrez Gene ID: 135
• Gene Name: adenosine A2a receptor
• Gene Aliases: A2aR, ADORA2, RDC8
• Location: Chr.22:24423597-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A	NM_000675.5	3	1152	NP_000666.2
	NM_001278497.1	4	1323	NP_001265426.1
	NM_001278498.1	3	1217	NP_001265427.1
	NM_001278499.1	3	1132	NP_001265428.1
	NM_001278500.1	3	999	NP_001265429.1
	NR_103543.1	2	546
	NR_103544.1	2	526
	AK123058.1	4	1062
	AK289871.1	4	1323
	AK301420.1	2	461
	AK312946.1	3	1090
	AY136747.1	2	693	AAN01273.1
	BC013780.1	3	1079	AAH13780.1
	BT006999.1	2	693	AAP35645.1
	CN408252.1	1	281
	CR456367.1	2	839	CAG30253.1
	DA687739.1	1	231
	DA983859.1	2	461
	HY102778.1
	KJ534761.1	2	693
	M97370.1	2	954	AAA58356.1

Target Gene Details

• Entrez Gene ID: 646023
• Gene Name: ADORA2A antisense RNA 1
• Gene Aliases: C22orf45
• Location: Chr.22:24429206-24495074 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A-AS1	NR_028483.2
	NR_028484.2
	DB449907.2

Target Gene Details

• Entrez Gene ID: 101730217
• Gene Name: SPECC1L-ADORA2A readthrough (NMD candidate)
• Gene Aliases: -
• Location: Chr.22:24270817-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPECC1L-ADORA2A	NR_103546.1	20	4872
	AB209022.1	20	4790	BAD92259.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv8039n54	Chr.22:23323169 - 24601506 on Build GRCh38	Gain	LOC101929374 DDTL MMP11 SNRPD3 SUSD2 ZNF70 IGLL1 POM121L9P LRRC75B PCAT14 SMARCB1 DRICH1 CES5AP1 UPB1 CABIN1 GUSBP11 DDT SPECC1L-ADORA2A GSTT2 CHCHD10 GUCD1 ZDHHC8P1 GSTTP1 ADORA2A GGT1 MIF ADORA2A-AS1 LOC388882 GGT5 VPREB3 DERL3 C22orf15 GSTT2B LOC107985555 LOC100652871 RGL4 SLC2A11 LOC107985559 SPECC1L MIF-AS1
esv2724068	Chr.22:24288741 - 24669870 on Build GRCh38	Deletion	POM121L10P BCRP3 UPB1 ADORA2A GGT1 SNRPD3 SPECC1L-ADORA2A ADORA2A-AS1 SPECC1L LRRC75B GUCD1
nsv1057819	Chr.22:24290518 - 24624081 on Build GRCh38	Gain	UPB1 ADORA2A GGT1 SNRPD3 SPECC1L-ADORA2A ADORA2A-AS1 SPECC1L LRRC75B GUCD1
esv2724041	Chr.22:23315914 - 24669376 on Build GRCh38	Deletion	LOC101929374 DDTL MMP11 SNRPD3 SUSD2 ZNF70 IGLL1 POM121L9P LRRC75B PCAT14 SMARCB1 DRICH1 BCRP3 CES5AP1 UPB1 CABIN1 GUSBP11 DDT SPECC1L-ADORA2A GSTT2 CHCHD10 GUCD1 ZDHHC8P1 GSTTP1 ADORA2A GGT1 MIF ADORA2A-AS1 LOC388882 GGT5 VPREB3 DERL3 C22orf15 POM121L10P GSTT2B BCR LOC107985555 LOC100652871 RGL4 SLC2A11 LOC107985559 SPECC1L MIF-AS1
nsv526567	Chr.22:23348138 - 24600663 on Build GRCh38	Gain	LOC101929374 DDTL MMP11 SNRPD3 SUSD2 ZNF70 IGLL1 POM121L9P LRRC75B PCAT14 SMARCB1 DRICH1 CES5AP1 UPB1 CABIN1 GUSBP11 DDT SPECC1L-ADORA2A GSTT2 CHCHD10 GUCD1 ZDHHC8P1 GSTTP1 ADORA2A GGT1 MIF ADORA2A-AS1 LOC388882 GGT5 VPREB3 DERL3 C22orf15 GSTT2B LOC107985555 LOC100652871 RGL4 SLC2A11 LOC107985559 SPECC1L MIF-AS1
nsv1055830	Chr.22:24005071 - 24643213 on Build GRCh38	Gain	GSTTP1 ADORA2A GGT1 SNRPD3 SUSD2 ADORA2A-AS1 GGT5 POM121L9P LRRC75B BCRP3 UPB1 CABIN1 SPECC1L-ADORA2A SPECC1L GUCD1
esv3893463	Chr.22:24009046 - 24601506 on Build GRCh38	Gain	ADORA2A GGT1 SNRPD3 SUSD2 ADORA2A-AS1 GGT5 POM121L9P LRRC75B UPB1 CABIN1 SPECC1L-ADORA2A SPECC1L GUCD1
dgv4528n100	Chr.22:23322244 - 24682765 on Build GRCh38	Gain	LOC101929374 DDTL MMP11 SNRPD3 SUSD2 ZNF70 IGLL1 POM121L9P LRRC75B PCAT14 SMARCB1 DRICH1 BCRP3 CES5AP1 UPB1 CABIN1 GUSBP11 DDT SPECC1L-ADORA2A GSTT2 CHCHD10 GUCD1 ZDHHC8P1 GSTTP1 ADORA2A GGT1 MIF ADORA2A-AS1 LOC388882 GGT5 VPREB3 DERL3 C22orf15 POM121L10P GSTT2B LOC107985555 LOC100652871 RGL4 SLC2A11 LOC107985559 SPECC1L MIF-AS1
nsv588744	Chr.22:24285587 - 24617379 on Build GRCh38	Gain	UPB1 ADORA2A GGT1 SNRPD3 SPECC1L-ADORA2A ADORA2A-AS1 SPECC1L LRRC75B GUCD1
esv3575443	Chr.22:23348201 - 24670505 on Build GRCh38	Gain	LOC101929374 DDTL MMP11 SNRPD3 SUSD2 ZNF70 IGLL1 POM121L9P LRRC75B PCAT14 SMARCB1 DRICH1 BCRP3 CES5AP1 UPB1 CABIN1 GUSBP11 DDT SPECC1L-ADORA2A GSTT2 CHCHD10 GUCD1 ZDHHC8P1 GSTTP1 ADORA2A GGT1 MIF ADORA2A-AS1 LOC388882 GGT5 VPREB3 DERL3 C22orf15 POM121L10P GSTT2B LOC107985555 LOC100652871 RGL4 SLC2A11 LOC107985559 SPECC1L MIF-AS1
nsv9884	Chr.22:24415625 - 24662249 on Build GRCh38	Gain+Loss	POM121L10P BCRP3 UPB1 ADORA2A GGT1 SNRPD3 SPECC1L-ADORA2A ADORA2A-AS1 SPECC1L LRRC75B GUCD1
nsv834160	Chr.22:24329972 - 24507687 on Build GRCh38	Gain	UPB1 ADORA2A SPECC1L-ADORA2A ADORA2A-AS1 SPECC1L

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

adenosine receptor signaling pathway
cAMP biosynthetic process
phagocytosis
apoptotic process
inflammatory response
cellular defense response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
central nervous system development
blood coagulation
sensory perception
blood circulation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
cellular protein metabolic process

Function(s)

G-protein coupled adenosine receptor activity
protein binding
enzyme binding
identical protein binding