Hs01759960_cn

• Gene Symbol: THPO
• Assay Reference Genome Location: Chr.3:184378095 on build GRCh38
• Cytoband: 3q27.1

Target Gene Details

• Entrez Gene ID: 7066
• Gene Name: thrombopoietin
• Gene Aliases: MGDF, MKCSF, ML, MPLLG, THCYT1, TPO
• Location: Chr.3:184371935-184379688 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
THPO	NM_000460.3			NP_000451.1
	NM_001177597.2			NP_001171068.1
	NM_001177598.2			NP_001171069.1
	NM_001289997.1			NP_001276926.1
	NM_001289998.1			NP_001276927.1
	NM_001290003.1			NP_001276932.1
	NM_001290022.1			NP_001276951.1
	NM_001290026.1			NP_001276955.1
	NM_001290027.1			NP_001276956.1
	NM_001290028.1			NP_001276957.1
	XM_017007107.1			XP_016862596.1
	BC130322.1
	BC136338.1
	BC143982.1
	L33410.1			AAA59857.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422400	Chr.3:184299495 - 184425713 on Build GRCh38	Duplication	LOC105374250 CHRD SNORD66 EIF4G1 FAM131A THPO POLR2H CLCN2 PSMD2
nsv829813	Chr.3:184264997 - 184427996 on Build GRCh38	Loss	LOC105374250 CHRD SNORD66 EIF4G1 FAM131A THPO POLR2H ECE2 CLCN2 PSMD2
nsv592667	Chr.3:184375988 - 184380341 on Build GRCh38	Loss	CHRD THPO

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
multicellular organism development
cell proliferation
myeloid cell differentiation
thrombopoietin-mediated signaling pathway
positive regulation of megakaryocyte differentiation
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
positive regulation of hematopoietic stem cell proliferation

Function(s)

cytokine activity
hormone activity
growth factor activity