Hs01954381_cn

• Gene Symbol: RIPK2
• Assay Reference Genome Location: Chr.8:89757864 on build GRCh38
• Cytoband: 8q21.3

Target Gene Details

• Entrez Gene ID: 8767
• Gene Name: receptor interacting serine/threonine kinase 2
• Gene Aliases: CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
• Location: Chr.8:89757747-89791064 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RIPK2	NM_003821.5	1	118	NP_003812.1
	XM_005251092.3	1	82	XP_005251149.1
	AF027706.1			AAC34970.1
	AF064824.1			AAC25668.1
	AK075213.1
	AK301448.1
	AY358813.1			AAQ89172.1
	AY358814.1	1	55	AAQ89173.1
	BC004553.2			AAH04553.1
	DA040898.1	1	118

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3576595	Chr.8:89459560 - 89771643 on Build GRCh38	Gain	LOC101929709 RIPK2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

activation of MAPK activity
positive regulation of cytokine-mediated signaling pathway
adaptive immune response
apoptotic process
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
JNK cascade
positive regulation of peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of immature T cell proliferation
positive regulation of peptidyl-serine phosphorylation
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
T cell proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
innate immune response
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding oligomerization domain containing 1 signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
response to interleukin-1
response to interleukin-12
response to interleukin-18
cellular response to lipoteichoic acid
cellular response to peptidoglycan
cellular response to muramyl dipeptide
positive regulation of xenophagy

Function(s)

protein serine/threonine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
receptor binding
protein binding
ATP binding
LIM domain binding
protein homodimerization activity
CARD domain binding