Hs01979720_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63532543 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Overlaps Intron 5 - Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	LOC102723788 LOC100130587 MIR124-3 MIR4326 COL20A1 HELZ2 FLJ16779 EEF1A2 CHRNA4 FNDC11 ARFGAP1 SRMS LOC107985425 LOC100130152 PTK6 YTHDF1 PPDPF MIR3196 NKAIN4 BIRC7 KCNQ2
nsv521734	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	SRMS PTK6 HELZ2 FNDC11
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	LOC102723788 DIDO1 OGFR-AS1 COL20A1 GMEB2 OGFR FLJ16779 LOC63930 ARFGAP1 LOC107985425 PTK6 YTHDF1 LINC01056 MIR3196 HAR1A LINC00659 LOC100130587 MIR124-3 GID8 COL9A3 MIR4326 HAR1B HELZ2 SLC17A9 DPH3P1 BHLHE23 EEF1A2 CHRNA4 FNDC11 SRMS LOC100130152 LOC107985428 PPDPF TCFL5 MRGBP LINC00029 NKAIN4 BIRC7 KCNQ2
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	ARFRP1 ZBTB46 LIME1 HELZ2 GMEB2 EEF1A2 FNDC11 ZGPAT TNFRSF6B SRMS LOC100505771 STMN3 PTK6 SLC2A4RG PPDPF RTEL1 RTEL1-TNFRSF6B
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	SRMS PTK6 PPDPF EEF1A2 FNDC11 KCNQ2
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	SRMS PTK6 PPDPF HELZ2 GMEB2 EEF1A2 FNDC11 KCNQ2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	SRMS PTK6 PPDPF EEF1A2
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	ARFRP1 ZBTB46 LIME1 HELZ2 GMEB2 EEF1A2 FNDC11 ZGPAT TNFRSF6B SRMS LOC100505771 STMN3 PTK6 SLC2A4RG PPDPF RTEL1 KCNQ2 RTEL1-TNFRSF6B

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding