Hs01979720_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63532543 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Overlaps Intron 5 - Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	EEF1A2 SRMS HELZ2 COL20A1 MIR4326 CHRNA4 LOC102723788 KCNQ2 LOC100130587 PPDPF LOC100130152 FLJ16779 PTK6 ARFGAP1 FNDC11 YTHDF1 MIR124-3 BIRC7 LOC107985425 NKAIN4 MIR3196
dgv521n27	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	SRMS FNDC11 HELZ2 PTK6
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	EEF1A2 HELZ2 TCFL5 DIDO1 COL20A1 LOC102723788 HAR1B LOC100130587 LINC00659 LOC100130152 PTK6 OGFR-AS1 FNDC11 YTHDF1 MIR124-3 LOC63930 LOC107985425 HAR1A NKAIN4 DPH3P1 MIR3196 SRMS OGFR GMEB2 MIR4326 CHRNA4 KCNQ2 BHLHE23 LOC107985428 GID8 PPDPF COL9A3 FLJ16779 ARFGAP1 MRGBP LINC00029 LINC01056 BIRC7 SLC17A9
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	EEF1A2 SRMS FNDC11 KCNQ2 PPDPF PTK6
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	EEF1A2 TNFRSF6B SRMS GMEB2 HELZ2 ARFRP1 ZBTB46 ZGPAT LOC100505771 LIME1 PPDPF PTK6 FNDC11 RTEL1-TNFRSF6B STMN3 SLC2A4RG RTEL1
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	EEF1A2 SRMS GMEB2 FNDC11 HELZ2 KCNQ2 PPDPF PTK6
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	EEF1A2 SRMS PPDPF PTK6
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	EEF1A2 TNFRSF6B SRMS GMEB2 HELZ2 ARFRP1 KCNQ2 ZBTB46 ZGPAT LOC100505771 LIME1 PPDPF PTK6 FNDC11 RTEL1-TNFRSF6B STMN3 SLC2A4RG RTEL1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding