Hs02026306_cn

• Gene Symbol: OGG1
• Assay Reference Genome Location: Chr.3:9784181 on build GRCh38
• Cytoband: 3p25.3

Target Gene Details

• Entrez Gene ID: 4968
• Gene Name: 8-oxoguanine DNA glycosylase
• Gene Aliases: HMMH, HOGG1, MUTM, OGH1
• Location: Chr.3:9749944-9788246 on Build GRCh38
• Assay Gene Location: Within Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
OGG1	XM_011533760.1			XP_011532062.1
	XM_017006499.1			XP_016861988.1

Target Gene Details

• Entrez Gene ID: 10474
• Gene Name: transcriptional adaptor 3
• Gene Aliases: ADA3, NGG1, STAF54, TADA3L, hADA3
• Location: Chr.3:9779964-9793011 on Build GRCh38
• Assay Gene Location: Overlaps Intron 7 - Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TADA3	NM_001278270.1			NP_001265199.1
	NM_006354.3			NP_006345.1
	NM_133480.2			NP_597814.1
	NR_103488.1
	AF069733.1			AAC39903.1
	AK000228.1
	AK024982.1
	AK292264.1
	AL117487.1			CAB55957.1
	BC009240.2			AAH09240.1
	BC013433.1			AAH13433.1
	BG477633.1
	CR533543.1			CAG38574.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1010768	Chr.3:9502870 - 9873902 on Build GRCh38	Gain	CIDEC LHFPL4 LOC107986062 ARPC4 TADA3 CAMK1 TTLL3 RPUSD3 CPNE9 ARPC4-TTLL3 MTMR14 OGG1 BRPF1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein, chromatin/chromatin-binding, or -regulatory protein, histone modifying enzyme

Gene Ontology Categories:

Process(es)

acute inflammatory response
base-excision repair
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
response to oxidative stress
aging
response to radiation
response to light stimulus
response to estradiol
regulation of protein import into nucleus, translocation
nucleotide-excision repair, DNA incision
response to drug
negative regulation of apoptotic process
depurination
depyrimidination
response to ethanol
response to folic acid
cellular response to cadmium ion
negative regulation of double-strand break repair via single-strand annealing
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mitotic nuclear division
positive regulation of gene expression
intracellular estrogen receptor signaling pathway
regulation of histone deacetylation
regulation of protein stability
histone H3 acetylation
positive regulation of transcription, DNA-templated
regulation of tubulin deacetylation

Function(s)

damaged DNA binding
endonuclease activity
protein binding
microtubule binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
oxidized purine DNA binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
histone acetyltransferase activity
ligand-dependent nuclear receptor binding
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity