Hs02056003_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31658080 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NM_019101.2			NP_061974.2
	NR_045828.1
	XM_006715150.3			XP_006715213.1
	AA476324.1
	AA846749.1
	AF118393.3			AAD11443.2
	AF161454.1			AAF29014.1
	AJ245434.1			CAB51604.1
	BC020683.1			AAH20683.1
	BF344944.1
	BG564719.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_017011279.1			XP_016866768.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv462871	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	MIR6832 C6orf47 AIF1 SNORA38 APOM GPANK1 PRRC2A BAG6
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	MIR1236 DDAH2 C6orf25 PRRC2A ATF6B GPSM3 LY6G5B TNXA VARS MIR4646 EGFL8 NOTCH4 SAPCD1-AS1 TNXB HCG23 C2-AS1 LOC100287329 VWA7 MIR6833 MCCD1 LY6G6D DDX39B LSM2 BAG6 MIR6832 SNORD48 NEU1 SNORA38 HLA-DRB1 C6orf48 HLA-DRA NCR3 EHMT2 AGPAT1 LST1 LTB MSH5-SAPCD1 HLA-DRB5 AIF1 LY6G6E LOC102725068 LY6G5C PBX2 HSPA1B LY6G6C C4B AGER FKBPL C2 STK19 DDX39B-AS1 MSH5 CLIC1 HSPA1L C4A C6orf10 SNORD84 SLC44A4 DXO HLA-DRB6 CSNK2B PPT2 NELFE MICB C6orf47 LOC100507547 ATP6V1G2 ABHD16A HCG26 APOM HSPA1A BTNL2 ZBTB12 NFKBIL1 LY6G6F SNORD52 MIR6721 TNF LOC101929163 PPT2-EGFL8 RNF5 PRRT1 GPANK1 CFB ATP6V1G2-DDX39B SKIV2L CYP21A2 LTA SAPCD1 CYP21A1P SNORD117 HCP5
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	MIR1236 DDAH2 RPS18 PHF1 VPS52 PRRC2A LY6G5B TNXA TAP1 MIR4646 EGFL8 NOTCH4 PFDN6 TNXB HCG23 HLA-DOB LOC100287329 MIR6833 DDX39B BAG6 SYNGAP1 ZBTB9 LOC100294145 SNORA38 NCR3 HLA-DQA2 EHMT2 AGPAT1 MSH5-SAPCD1 RGL2 HSD17B8 AIF1 LOC102725068 MIR5004 LY6G5C PBX2 HLA-DQB1 HSPA1B B3GALT4 MIR3135B C4B AGER FKBPL C2 WDR46 PSMB9 HCG24 MSH5 HLA-DMA HSPA1L C6orf10 SLC39A7 SNORD84 DXO HLA-DRB6 APOM HSPA1A BTNL2 ZBTB12 HLA-DQB2 NFKBIL1 LOC101929163 TAPBP ZBTB22 MIR6873 PRRT1 CUTA SKIV2L LTA KIFC1 SAPCD1 HCG25 COL11A2 SNORD117 MIR219A1 PSMB8 C6orf25 ATF6B GPSM3 VARS SAPCD1-AS1 C2-AS1 VWA7 MCCD1 LY6G6D LSM2 MIR6832 SNORD48 BRD2 NEU1 HLA-DRB1 C6orf48 RING1 HLA-DRA LST1 LTB HLA-DQB1-AS1 HLA-DPB1 HLA-DRB5 HLA-DPA1 LY6G6E DAXX TAP2 LY6G6C STK19 HLA-DQA1 DDX39B-AS1 CLIC1 C4A SLC44A4 RXRB CSNK2B PPT2 NELFE MICB C6orf47 LOC100507547 ATP6V1G2 ABHD16A HCG26 MIR6834 LY6G6F SNORD52 MIR6721 TNF PPT2-EGFL8 RNF5 GPANK1 HLA-DOA CFB ATP6V1G2-DDX39B PPP1R2P1 CYP21A2 HLA-DPB2 PSMB8-AS1 CYP21A1P HCP5 HLA-DMB
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	MIR1236 DDAH2 C6orf25 PRRC2A LY6G5B TNXA VARS MIR4646 SAPCD1-AS1 TNXB C2-AS1 LOC100287329 VWA7 MCCD1 LY6G6D DDX39B LSM2 BAG6 MIR6832 SNORD48 NEU1 SNORA38 C6orf48 NCR3 MICA EHMT2 LST1 LTB MSH5-SAPCD1 AIF1 LY6G6E LOC102725068 LY6G5C HLA-B HSPA1B LY6G6C C4B C2 STK19 DDX39B-AS1 MSH5 CLIC1 HSPA1L C4A SNORD84 SLC44A4 DXO CSNK2B NELFE MICB C6orf47 ATP6V1G2 ABHD16A HCG26 APOM HSPA1A ZBTB12 NFKBIL1 LY6G6F SNORD52 TNF MIR6891 GPANK1 CFB ATP6V1G2-DDX39B SKIV2L CYP21A2 LTA SAPCD1 CYP21A1P SNORD117 HCP5
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	MIR1236 DDAH2 RPS18 PHF1 VPS52 PRRC2A LY6G5B TNXA TAP1 MIR4646 EGFL8 NOTCH4 PFDN6 TNXB HCG23 HLA-DOB LOC100287329 MIR6833 DDX39B BAG6 SYNGAP1 ZBTB9 LOC100294145 SNORA38 NCR3 HLA-DQA2 EHMT2 AGPAT1 MSH5-SAPCD1 RGL2 HSD17B8 AIF1 LOC102725068 MIR5004 LY6G5C PBX2 HLA-DQB1 HSPA1B B3GALT4 MIR3135B C4B AGER FKBPL C2 WDR46 PSMB9 HCG24 MSH5 HLA-DMA HSPA1L C6orf10 SLC39A7 SNORD84 DXO HLA-DRB6 APOM HSPA1A BTNL2 ZBTB12 HLA-DQB2 NFKBIL1 LOC101929163 TAPBP ZBTB22 MIR6873 PRRT1 CUTA SKIV2L LTA KIFC1 SAPCD1 HCG25 COL11A2 SNORD117 MIR219A1 PSMB8 C6orf25 ATF6B GPSM3 VARS SAPCD1-AS1 C2-AS1 VWA7 MCCD1 LY6G6D LSM2 MIR6832 SNORD48 BRD2 NEU1 HLA-DRB1 C6orf48 RING1 HLA-DRA LST1 LTB HLA-DQB1-AS1 HLA-DPB1 HLA-DRB5 HLA-DPA1 LY6G6E DAXX TAP2 LY6G6C STK19 HLA-DQA1 DDX39B-AS1 CLIC1 C4A SLC44A4 RXRB CSNK2B PPT2 NELFE MICB C6orf47 LOC100507547 ATP6V1G2 ABHD16A HCG26 MIR6834 LY6G6F SNORD52 MIR6721 TNF PPT2-EGFL8 RNF5 GPANK1 HLA-DOA CFB ATP6V1G2-DDX39B PPP1R2P1 CYP21A2 HLA-DPB2 PSMB8-AS1 CYP21A1P HCP5 HLA-DMB
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	MIR1236 DDAH2 C6orf25 PRRC2A ATF6B GPSM3 LY6G5B TNXA VARS MIR4646 EGFL8 NOTCH4 SAPCD1-AS1 TNXB HCG23 C2-AS1 LOC100287329 VWA7 MIR6833 MCCD1 LY6G6D DDX39B LSM2 BAG6 MIR6832 SNORD48 NEU1 SNORA38 C6orf48 HLA-DRA NCR3 MICA EHMT2 AGPAT1 LST1 LTB MSH5-SAPCD1 AIF1 LY6G6E LOC102725068 LY6G5C PBX2 HLA-B HSPA1B LY6G6C C4B AGER FKBPL C2 STK19 DDX39B-AS1 MSH5 CLIC1 HSPA1L C4A C6orf10 SNORD84 SLC44A4 DXO CSNK2B PPT2 NELFE MICB C6orf47 LOC100507547 ATP6V1G2 ABHD16A HCG26 APOM HSPA1A BTNL2 ZBTB12 NFKBIL1 LY6G6F SNORD52 MIR6721 TNF LOC101929163 MIR6891 PPT2-EGFL8 RNF5 PRRT1 GPANK1 CFB ATP6V1G2-DDX39B SKIV2L CYP21A2 LTA SAPCD1 CYP21A1P SNORD117 HCP5
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	MIR6832 LY6G6F SNORA38 GPANK1 PRRC2A LY6G5B CSNK2B C6orf47 AIF1 MIR4646 LY6G6E ABHD16A LY6G5C APOM BAG6
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	DDX39B-AS1 PRRC2A SNORD84 LY6G5B CSNK2B C6orf47 ATP6V1G2 ABHD16A LOC100287329 MCCD1 APOM DDX39B BAG6 NFKBIL1 MIR6832 TNF SNORA38 NCR3 GPANK1 LST1 LTB ATP6V1G2-DDX39B AIF1 LTA LY6G5C SNORD117

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding