Hs02056003_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31658080 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NM_019101.2			NP_061974.2
	NR_045828.1
	XM_006715150.3			XP_006715213.1
	AA476324.1
	AA846749.1
	AF118393.3			AAD11443.2
	AF161454.1			AAF29014.1
	AJ245434.1			CAB51604.1
	BC020683.1			AAH20683.1
	BF344944.1
	BG564719.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_017011279.1			XP_016866768.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	TNF LOC100287329 LST1 AGPAT1 LY6G6E C4A SNORA38 SNORD52 CSNK2B RNF5 MICB LY6G6C PBX2 NEU1 CYP21A2 DDX39B-AS1 HLA-DRB5 PPT2 C6orf25 HLA-DRA C2 HLA-DRB1 HSPA1A VWA7 C6orf10 LY6G6D MIR6832 CYP21A1P PPT2-EGFL8 LSM2 MIR6721 HCP5 SNORD117 MIR1236 HCG23 LTB MIR6833 EHMT2 AGER LTA CLIC1 HLA-DRB6 MCCD1 LOC102725068 SKIV2L BTNL2 ZBTB12 HSPA1B MSH5-SAPCD1 NCR3 NFKBIL1 GPSM3 CFB EGFL8 LOC101929163 ABHD16A VARS ATF6B SAPCD1 SNORD48 SNORD84 TNXA C6orf48 SLC44A4 LY6G5C C2-AS1 C6orf47 LOC100507547 ATP6V1G2 STK19 BAG6 LY6G5B DDAH2 SAPCD1-AS1 HSPA1L NOTCH4 DDX39B AIF1 PRRC2A HCG26 ATP6V1G2-DDX39B DXO GPANK1 PRRT1 MIR4646 C4B FKBPL LY6G6F APOM MSH5 TNXB NELFE
nsv601942	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	AIF1 PRRC2A C6orf47 GPANK1 APOM BAG6 SNORA38 MIR6832
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	TNF LOC100287329 LST1 LY6G6E C4A SNORA38 SNORD52 CSNK2B MICB LY6G6C MICA NEU1 CYP21A2 DDX39B-AS1 C6orf25 C2 HSPA1A VWA7 LY6G6D MIR6832 CYP21A1P LSM2 HCP5 SNORD117 MIR1236 LTB EHMT2 LTA CLIC1 MCCD1 LOC102725068 SKIV2L ZBTB12 HSPA1B MSH5-SAPCD1 NCR3 NFKBIL1 CFB ABHD16A VARS SAPCD1 SNORD48 SNORD84 TNXA C6orf48 SLC44A4 LY6G5C C2-AS1 C6orf47 ATP6V1G2 STK19 BAG6 LY6G5B DDAH2 SAPCD1-AS1 HSPA1L DDX39B AIF1 PRRC2A HCG26 ATP6V1G2-DDX39B DXO GPANK1 MIR4646 MIR6891 C4B LY6G6F APOM MSH5 TNXB NELFE HLA-B
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	TNF LOC100287329 AGPAT1 MIR6834 SNORA38 RNF5 MICB MIR6873 NEU1 DDX39B-AS1 HLA-DQA1 PPT2 HLA-DRB1 HSPA1A LY6G6D RXRB CYP21A1P PPT2-EGFL8 HLA-DMA LSM2 SNORD117 MIR1236 RGL2 PSMB8 AGER HLA-DQB1 LTA WDR46 MCCD1 SKIV2L SLC39A7 PSMB9 ZBTB12 HLA-DPA1 HSPA1B MSH5-SAPCD1 NCR3 ZBTB22 EGFL8 VARS ATF6B MIR3135B SNORD48 TNXA HLA-DOB SLC44A4 C2-AS1 C6orf47 COL11A2 LOC100507547 ATP6V1G2 BAG6 SAPCD1-AS1 DDX39B PPP1R2P1 TAPBP ZBTB9 HCG26 ATP6V1G2-DDX39B DXO PRRT1 MIR4646 FKBPL LY6G6F MSH5 TAP2 NELFE B3GALT4 LST1 HLA-DQB2 PSMB8-AS1 LY6G6E C4A SNORD52 CSNK2B HCG24 SYNGAP1 VPS52 TAP1 HLA-DPB1 RPS18 HSD17B8 RING1 LY6G6C MIR219A1 PBX2 CYP21A2 HLA-DRB5 C6orf25 HLA-DRA C2 VWA7 C6orf10 MIR6832 KIFC1 BRD2 MIR6721 HCP5 HCG23 LTB MIR6833 EHMT2 CLIC1 HLA-DRB6 LOC102725068 BTNL2 HCG25 HLA-DPB2 NFKBIL1 GPSM3 HLA-DOA CFB HLA-DMB PFDN6 LOC101929163 ABHD16A SAPCD1 PHF1 DAXX SNORD84 C6orf48 LY6G5C HLA-DQA2 STK19 LY6G5B DDAH2 CUTA HSPA1L NOTCH4 AIF1 PRRC2A MIR5004 GPANK1 C4B APOM HLA-DQB1-AS1 TNXB LOC100294145
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	TNF LOC100287329 AGPAT1 MIR6834 SNORA38 RNF5 MICB MIR6873 NEU1 DDX39B-AS1 HLA-DQA1 PPT2 HLA-DRB1 HSPA1A LY6G6D RXRB CYP21A1P PPT2-EGFL8 HLA-DMA LSM2 SNORD117 MIR1236 RGL2 PSMB8 AGER HLA-DQB1 LTA WDR46 MCCD1 SKIV2L SLC39A7 PSMB9 ZBTB12 HLA-DPA1 HSPA1B MSH5-SAPCD1 NCR3 ZBTB22 EGFL8 VARS ATF6B MIR3135B SNORD48 TNXA HLA-DOB SLC44A4 C2-AS1 C6orf47 COL11A2 LOC100507547 ATP6V1G2 BAG6 SAPCD1-AS1 DDX39B PPP1R2P1 TAPBP ZBTB9 HCG26 ATP6V1G2-DDX39B DXO PRRT1 MIR4646 FKBPL LY6G6F MSH5 TAP2 NELFE B3GALT4 LST1 HLA-DQB2 PSMB8-AS1 LY6G6E C4A SNORD52 CSNK2B HCG24 SYNGAP1 VPS52 TAP1 HLA-DPB1 RPS18 HSD17B8 RING1 LY6G6C MIR219A1 PBX2 CYP21A2 HLA-DRB5 C6orf25 HLA-DRA C2 VWA7 C6orf10 MIR6832 KIFC1 BRD2 MIR6721 HCP5 HCG23 LTB MIR6833 EHMT2 CLIC1 HLA-DRB6 LOC102725068 BTNL2 HCG25 HLA-DPB2 NFKBIL1 GPSM3 HLA-DOA CFB HLA-DMB PFDN6 LOC101929163 ABHD16A SAPCD1 PHF1 DAXX SNORD84 C6orf48 LY6G5C HLA-DQA2 STK19 LY6G5B DDAH2 CUTA HSPA1L NOTCH4 AIF1 PRRC2A MIR5004 GPANK1 C4B APOM HLA-DQB1-AS1 TNXB LOC100294145
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	TNF LOC100287329 LST1 AGPAT1 LY6G6E C4A SNORA38 SNORD52 CSNK2B RNF5 MICB LY6G6C MICA PBX2 NEU1 CYP21A2 DDX39B-AS1 PPT2 C6orf25 HLA-DRA C2 HSPA1A VWA7 C6orf10 LY6G6D MIR6832 CYP21A1P PPT2-EGFL8 LSM2 MIR6721 HCP5 SNORD117 MIR1236 HCG23 LTB MIR6833 EHMT2 AGER LTA CLIC1 MCCD1 LOC102725068 SKIV2L BTNL2 ZBTB12 HSPA1B MSH5-SAPCD1 NCR3 NFKBIL1 GPSM3 CFB EGFL8 LOC101929163 ABHD16A VARS ATF6B SAPCD1 SNORD48 SNORD84 TNXA C6orf48 SLC44A4 LY6G5C C2-AS1 C6orf47 LOC100507547 ATP6V1G2 STK19 BAG6 LY6G5B DDAH2 SAPCD1-AS1 HSPA1L NOTCH4 DDX39B AIF1 PRRC2A HCG26 ATP6V1G2-DDX39B DXO GPANK1 PRRT1 MIR4646 MIR6891 C4B FKBPL LY6G6F APOM MSH5 TNXB NELFE HLA-B
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	LY6G5C C6orf47 LY6G6E BAG6 LY6G5B SNORA38 CSNK2B MIR6832 AIF1 PRRC2A GPANK1 ABHD16A MIR4646 LY6G6F APOM
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	TNF LOC100287329 LTA LST1 MCCD1 SNORA38 NCR3 CSNK2B NFKBIL1 ABHD16A SNORD84 DDX39B-AS1 LY6G5C C6orf47 ATP6V1G2 BAG6 LY6G5B MIR6832 DDX39B AIF1 PRRC2A ATP6V1G2-DDX39B GPANK1 APOM SNORD117 LTB

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding