Hs02186952_cn

• Gene Symbol: TNFSF10
• Assay Reference Genome Location: Chr.3:172506097 on build GRCh38
• Cytoband: 3q26.31

Target Gene Details

• Entrez Gene ID: 8743
• Gene Name: tumor necrosis factor superfamily member 10
• Gene Aliases: APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL
• Location: Chr.3:172505508-172523507 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFSF10	NM_001190942.1	3	1216	NP_001177871.1
	NM_003810.3	5	1364	NP_003801.1
	NR_033994.1	4	1321
	AK296085.1	3	1184
	BC032722.1	5	1316	AAH32722.1
	U37518.1	5	1328	AAC50332.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829794	Chr.3:172441561 - 172607903 on Build GRCh38	Gain	TNFSF10 GHSR

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
immune response
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of release of cytochrome c from mitochondria
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

receptor binding
cytokine activity
tumor necrosis factor receptor binding
protein binding
metal ion binding