Hs02294428_cn

• Gene Symbol: HSP90AA1
• Assay Reference Genome Location: Chr.14:102139650 on build GRCh38
• Cytoband: 14q32.31

Target Gene Details

• Entrez Gene ID: 3320
• Gene Name: heat shock protein 90 alpha family class A member 1
• Gene Aliases: EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
• Location: Chr.14:102080738-102139749 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HSP90AA1	NM_001017963.2	1	100	NP_001017963.2
	XM_011536718.2	1	100	XP_011535020.1
	AJ890082.1	1	37	CAI64495.1
	AK056446.1	1	37
	BX248761.1	1	36	CAD66568.1
	DA237149.1	1	100

Target Gene Details

• Entrez Gene ID: 91833
• Gene Name: WD repeat domain 20
• Gene Aliases: DMR
• Location: Chr.14:102139518-102224686 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
WDR20	XM_017021777.1			XP_016877266.1
	XM_017021780.1	1	133	XP_016877269.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv565947	Chr.14:102001510 - 102204240 on Build GRCh38	Gain	DYNC1H1 WDR20 HSP90AA1
dgv25n68	Chr.14:102000993 - 102195522 on Build GRCh38	Loss	DYNC1H1 WDR20 HSP90AA1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

Hsp90 family chaperone

Gene Ontology Categories:

Process(es)

G2/M transition of mitotic cell cycle
neuron migration
skeletal muscle contraction
mitochondrial transport
receptor-mediated endocytosis
response to unfolded protein
signal transduction
response to heat
response to cold
response to salt stress
positive regulation of lamellipodium assembly
cardiac muscle cell apoptotic process
peptidyl-tyrosine phosphorylation
regulation of protein ubiquitination
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
protein refolding
regulation of protein complex assembly
protein unfolding
response to estrogen
protein import into mitochondrial outer membrane
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
response to antibiotic
vascular endothelial growth factor receptor signaling pathway
protein stabilization
regulation of nitric-oxide synthase activity
chaperone-mediated protein complex assembly
positive regulation of cardiac muscle contraction
chaperone-mediated autophagy
regulation of cellular response to heat

Function(s)

nucleotide binding
UTP binding
CTP binding
mRNA binding
protein tyrosine kinase activity
protein binding
ATP binding
GTP binding
ATPase activity
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
unfolded protein binding