Hs02316480_cn

• Gene Symbol: ADRA2B
• Assay Reference Genome Location: Chr.2:96113174 on build GRCh38
• Cytoband: 2q11.2

Target Gene Details

• Entrez Gene ID: 151
• Gene Name: adrenoceptor alpha 2B
• Gene Aliases: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
• Location: Chr.2:96112875-96116245 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2B	NM_000682.6	1	3072	NP_000673.2
	BC133021.1	1	3072
	BC136537.1	1	3072

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv607e201	Chr.2:95855884 - 97561622 on Build GRCh38	Deletion	CNNM3 LOC100506123 LOC101927053 ANKRD39 ANKRD36B LOC105373496 ANKRD23 LOC653924 CNNM4 CIAO1 ANKRD36C ADRA2B SNRNP200 STARD7 DUSP2 LOC100506076 FER1L5 ANKRD36 GPAT2 KANSL3 NCAPH SEMA4C LMAN2L TMEM127 FAM178B FAHD2B MIR3127 STARD7-AS1 FAHD2CP NEURL3 LOC105373495 ASTL ARID5A LOC107984110 ITPRIPL1
dgv4009n100	Chr.2:96072837 - 96159625 on Build GRCh38	Gain	ASTL ADRA2B DUSP2
nsv2834	Chr.2:96107177 - 96119371 on Build GRCh38	Deletion	ADRA2B
nsv1135873	Chr.2:95981454 - 97579645 on Build GRCh38	Deletion	CNNM3 LOC100506123 LOC101927053 ANKRD39 ANKRD36B LOC105373496 ANKRD23 LOC653924 CNNM4 CIAO1 ANKRD36C ADRA2B SNRNP200 STARD7 DUSP2 LOC100506076 FER1L5 ANKRD36 GPAT2 KANSL3 NCAPH SEMA4C LMAN2L TMEM127 FAM178B FAHD2B MIR3127 STARD7-AS1 FAHD2CP NEURL3 LOC105373495 ASTL ARID5A LOC107984110 ITPRIPL1
esv3425717	Chr.2:95859900 - 97515905 on Build GRCh38	Duplication	CNNM3 LOC100506123 LOC101927053 ANKRD39 ANKRD36B LOC105373496 ANKRD23 LOC653924 CNNM4 CIAO1 ANKRD36C ADRA2B SNRNP200 STARD7 DUSP2 LOC100506076 FER1L5 ANKRD36 GPAT2 KANSL3 NCAPH SEMA4C LMAN2L TMEM127 FAM178B FAHD2B MIR3127 STARD7-AS1 FAHD2CP NEURL3 LOC105373495 ASTL ARID5A LOC107984110 ITPRIPL1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
epinephrine binding