Hs02321393_cn

• Gene Symbol: SIRT3
• Assay Reference Genome Location: Chr.11:216027 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 23410
• Gene Name: sirtuin 3
• Gene Aliases: SIR2L3
• Location: Chr.11:215030-236950 on Build GRCh38
• Assay Gene Location: Within Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIRT3	NM_001017524.2	7	1759	NP_001017524.1
	NM_012239.5	7	1905	NP_036371.1
	XM_005252835.1	7	1959	XP_005252892.1
	XM_011519956.1	7	2751	XP_011518258.1
	XM_011519957.1	7	2580	XP_011518259.1
	XM_017017428.1	7	1805	XP_016872917.1
	XM_017017429.1	7	1979	XP_016872918.1
	XM_017017430.1	7	1919	XP_016872919.1
	XM_017017431.1	7	1704	XP_016872920.1
	BM709066.1	1	126
	DR762907.1	1	619

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3625061	Chr.11:195766 - 233956 on Build GRCh38	Gain	MIR6743 SIRT3 RIC8A ODF3 BET1L
esv3625060	Chr.11:194412 - 252166 on Build GRCh38	Gain	MIR6743 SIRT3 RIC8A ODF3 PSMD13 SCGB1C1 BET1L
nsv552765	Chr.11:199256 - 320836 on Build GRCh38	Gain	IFITM5 MIR6743 SIRT3 RIC8A IFITM2 ODF3 IFITM3 PSMD13 NLRP6 IFITM1 PGGHG BET1L
dgv1011n100	Chr.11:198510 - 275185 on Build GRCh38	Gain	MIR6743 SIRT3 RIC8A ODF3 PSMD13 BET1L
esv22231	Chr.11:60059 - 216243 on Build GRCh38	Gain	MIR6743 SIRT3 RIC8A ODF3 LINC01001 LOC388572 SCGB1C1 BET1L

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
protein deacetylation
mitochondrion organization
aerobic respiration
peptidyl-lysine deacetylation
histone H3 deacetylation
negative regulation of peptidyl-lysine acetylation

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NAD+ binding