Hs02421422_cn

• Gene Symbol: CTTN
• Assay Reference Genome Location: Chr.11:70421497 on build GRCh38
• Cytoband: 11q13.3

Target Gene Details

• Entrez Gene ID: 2017
• Gene Name: cortactin
• Gene Aliases: EMS1
• Location: Chr.11:70398506-70436584 on Build GRCh38
• Assay Gene Location: Overlaps Intron 10 - Exon 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CTTN	NM_001184740.1			NP_001171669.1
	NM_005231.3			NP_005222.2
	NM_138565.2			NP_612632.1
	XM_006718447.2			XP_006718510.1
	XM_006718448.3			XP_006718511.1
	XM_017017312.1			XP_016872801.1
	AK222613.1			BAD96333.1
	AK291097.1
	AK304582.1
	BC008799.2			AAH08799.1
	BC033889.1			AAH33889.1
	LN607836.1
	M98343.1			AAA58455.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3579739	Chr.11:70420920 - 70422921 on Build GRCh38	Loss	CTTN

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

actin or actin-binding cytoskeletal protein, cytoskeletal protein, non-motor actin binding protein

Gene Ontology Categories:

Process(es)

intracellular protein transport
receptor-mediated endocytosis
substrate-dependent cell migration, cell extension
actin filament polymerization
regulation of axon extension
positive regulation of actin filament polymerization
actin cytoskeleton reorganization
positive regulation of smooth muscle contraction
focal adhesion assembly
neuron projection morphogenesis
cell motility
dendritic spine maintenance
lamellipodium organization
cell-cell adhesion
regulation of mitophagy
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

protein binding
profilin binding
cadherin binding involved in cell-cell adhesion