Hs02422726_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4258129 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Within Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2	7	1197	NP_003214.1
	XM_011522633.2	7	1333	XP_011520935.1
	XM_011522635.2	7	1013	XP_011520937.1
	AB209146.1	5	5548	BAD92383.1
	BC010576.1	7	1086	AAH10576.1
	CR541726.1	7	943	CAG46527.1
	S73885.1	7	1201	AAB32235.1
	X57435.1	7	892	CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	NAGPA UBALD1 VASN NAGPA-AS1 LINC01569 RBFOX1 LOC105371063 SRL ANKS3 C16orf89 HMOX2 UBN1 TFAP4 SEC14L5 GLIS2 NUDT16L1 GLYR1 CORO7 CDIP1 DNAJA3 PAM16 GLIS2-AS1 SEPT12 C16orf96 C16orf71 ROGDI ADCY9 NMRAL1 SMIM22 ZNF500 PPL MIR6769A ALG1 MGRN1 EEF2KMT CORO7-PAM16
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	LOC102724927 LINC01569 CREBBP TFAP4 LOC105371063 ADCY9 SRL
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	CORO7 VASN PAM16 LINC01569 GLIS2-AS1 TFAP4 LOC105371063 GLIS2 CORO7-PAM16 SRL

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding