Hs02423480_cn

• Gene Symbol: ADORA2A
• Assay Reference Genome Location: Chr.22:24441080 on build GRCh38
• Cytoband: 22q11.23

Target Gene Details

• Entrez Gene ID: 135
• Gene Name: adenosine A2a receptor
• Gene Aliases: A2aR, ADORA2, RDC8
• Location: Chr.22:24423597-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A	NM_000675.5	3	1289	NP_000666.2
	NM_001278497.1	4	1460	NP_001265426.1
	NM_001278498.1	3	1354	NP_001265427.1
	NM_001278499.1	3	1269	NP_001265428.1
	NM_001278500.1	3	1136	NP_001265429.1
	NR_103543.1	2	683
	NR_103544.1	2	663
	AK123058.1	4	1199
	AK289871.1	4	1460
	AK301420.1	2	598
	AK312946.1	3	1227
	AY136747.1	2	830	AAN01273.1
	BC013780.1	3	1216	AAH13780.1
	BG686029.1	1	40
	BT006999.1	2	830	AAP35645.1
	CN408252.1	1	418
	CR456367.1	2	976	CAG30253.1
	DA687739.1	1	368
	KJ534761.1	2	830
	M97370.1	2	1091	AAA58356.1

Target Gene Details

• Entrez Gene ID: 646023
• Gene Name: ADORA2A antisense RNA 1
• Gene Aliases: C22orf45
• Location: Chr.22:24429206-24495074 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A-AS1	NR_028483.2
	NR_028484.2
	DB449907.2

Target Gene Details

• Entrez Gene ID: 101730217
• Gene Name: SPECC1L-ADORA2A readthrough (NMD candidate)
• Gene Aliases: -
• Location: Chr.22:24270817-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPECC1L-ADORA2A	NR_103546.1	20	5009
	AB209022.1	20	4927	BAD92259.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2724068	Chr.22:24288741 - 24669870 on Build GRCh38	Deletion	SPECC1L SPECC1L-ADORA2A ADORA2A-AS1 BCRP3 LRRC75B POM121L10P GUCD1 UPB1 GGT1 SNRPD3 ADORA2A
dgv8039n54	Chr.22:23323169 - 24601506 on Build GRCh38	Gain	SPECC1L-ADORA2A ADORA2A-AS1 SNRPD3 DERL3 POM121L9P SMARCB1 DDT GUSBP11 CHCHD10 GSTTP1 CES5AP1 SPECC1L PCAT14 VPREB3 GGT5 ADORA2A LOC107985555 SUSD2 ZNF70 LOC101929374 LOC388882 MMP11 LRRC75B LOC107985559 ZDHHC8P1 MIF GUCD1 SLC2A11 UPB1 GSTT2 CABIN1 DRICH1 C22orf15 MIF-AS1 RGL4 GGT1 IGLL1 GSTT2B LOC100652871 DDTL
nsv1057819	Chr.22:24290518 - 24624081 on Build GRCh38	Gain	SPECC1L SPECC1L-ADORA2A ADORA2A-AS1 LRRC75B GUCD1 UPB1 GGT1 SNRPD3 ADORA2A
nsv526567	Chr.22:23348138 - 24600663 on Build GRCh38	Gain	SPECC1L-ADORA2A ADORA2A-AS1 SNRPD3 DERL3 POM121L9P SMARCB1 DDT GUSBP11 CHCHD10 GSTTP1 CES5AP1 SPECC1L PCAT14 VPREB3 GGT5 ADORA2A LOC107985555 SUSD2 ZNF70 LOC101929374 LOC388882 MMP11 LRRC75B LOC107985559 ZDHHC8P1 MIF GUCD1 SLC2A11 UPB1 GSTT2 CABIN1 DRICH1 C22orf15 MIF-AS1 RGL4 GGT1 IGLL1 GSTT2B LOC100652871 DDTL
esv2724041	Chr.22:23315914 - 24669376 on Build GRCh38	Deletion	SPECC1L-ADORA2A ADORA2A-AS1 SNRPD3 DERL3 POM121L9P SMARCB1 DDT GUSBP11 CHCHD10 GSTTP1 CES5AP1 SPECC1L POM121L10P BCR PCAT14 VPREB3 GGT5 ADORA2A LOC107985555 SUSD2 ZNF70 LOC101929374 LOC388882 MMP11 BCRP3 LRRC75B LOC107985559 ZDHHC8P1 MIF GUCD1 SLC2A11 UPB1 GSTT2 CABIN1 DRICH1 C22orf15 MIF-AS1 RGL4 GGT1 IGLL1 GSTT2B LOC100652871 DDTL
nsv1055830	Chr.22:24005071 - 24643213 on Build GRCh38	Gain	SPECC1L-ADORA2A ADORA2A-AS1 BCRP3 LRRC75B GUCD1 UPB1 SNRPD3 POM121L9P CABIN1 GSTTP1 SPECC1L GGT5 GGT1 ADORA2A SUSD2
esv3893463	Chr.22:24009046 - 24601506 on Build GRCh38	Gain	SPECC1L-ADORA2A ADORA2A-AS1 LRRC75B GUCD1 UPB1 SNRPD3 POM121L9P CABIN1 SPECC1L GGT5 GGT1 ADORA2A SUSD2
dgv4528n100	Chr.22:23322244 - 24682765 on Build GRCh38	Gain	SPECC1L-ADORA2A ADORA2A-AS1 SNRPD3 DERL3 POM121L9P SMARCB1 DDT GUSBP11 CHCHD10 GSTTP1 CES5AP1 SPECC1L POM121L10P PCAT14 VPREB3 GGT5 ADORA2A LOC107985555 SUSD2 ZNF70 LOC101929374 LOC388882 MMP11 BCRP3 LRRC75B LOC107985559 ZDHHC8P1 MIF GUCD1 SLC2A11 UPB1 GSTT2 CABIN1 DRICH1 C22orf15 MIF-AS1 RGL4 GGT1 IGLL1 GSTT2B LOC100652871 DDTL
nsv588744	Chr.22:24285587 - 24617379 on Build GRCh38	Gain	SPECC1L SPECC1L-ADORA2A ADORA2A-AS1 LRRC75B GUCD1 UPB1 GGT1 SNRPD3 ADORA2A
nsv9884	Chr.22:24415625 - 24662249 on Build GRCh38	Gain+Loss	SPECC1L SPECC1L-ADORA2A ADORA2A-AS1 BCRP3 LRRC75B POM121L10P GUCD1 UPB1 GGT1 SNRPD3 ADORA2A
esv3575443	Chr.22:23348201 - 24670505 on Build GRCh38	Gain	SPECC1L-ADORA2A ADORA2A-AS1 SNRPD3 DERL3 POM121L9P SMARCB1 DDT GUSBP11 CHCHD10 GSTTP1 CES5AP1 SPECC1L POM121L10P PCAT14 VPREB3 GGT5 ADORA2A LOC107985555 SUSD2 ZNF70 LOC101929374 LOC388882 MMP11 BCRP3 LRRC75B LOC107985559 ZDHHC8P1 MIF GUCD1 SLC2A11 UPB1 GSTT2 CABIN1 DRICH1 C22orf15 MIF-AS1 RGL4 GGT1 IGLL1 GSTT2B LOC100652871 DDTL
nsv834160	Chr.22:24329972 - 24507687 on Build GRCh38	Gain	SPECC1L SPECC1L-ADORA2A ADORA2A-AS1 UPB1 ADORA2A

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

adenosine receptor signaling pathway
cAMP biosynthetic process
phagocytosis
apoptotic process
inflammatory response
cellular defense response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
central nervous system development
blood coagulation
sensory perception
blood circulation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
cellular protein metabolic process

Function(s)

G-protein coupled adenosine receptor activity
protein binding
enzyme binding
identical protein binding