Hs02522043_cn

• Gene Symbol: MRPS25
• Assay Reference Genome Location: Chr.3:15048905 on build GRCh38
• Cytoband: 3p25.1

Target Gene Details

• Entrez Gene ID: 64432
• Gene Name: mitochondrial ribosomal protein S25
• Gene Aliases: MRP-S25, RPMS25
• Location: Chr.3:15042251-15065337 on Build GRCh38
• Assay Gene Location: Within Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MRPS25	NM_022497.4	4	4201	NP_071942.1
	NR_135246.1
	NR_135247.1
	AI288348.1
	AK024433.1	4	4116

Target Gene Details

• Entrez Gene ID: 7182
• Gene Name: nuclear receptor subfamily 2 group C member 2
• Gene Aliases: TAK1, TR4
• Location: Chr.3:14947584-15049279 on Build GRCh38
• Assay Gene Location: Within Exon 21

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NR2C2	NM_001291694.1	14	8050	NP_001278623.1
	NM_003298.4	15	8107	NP_003289.2
	XM_011534058.2	18	8142	XP_011532360.1
	XM_011534059.2	18	9048	XP_011532361.1
	XM_011534061.2	16	7996	XP_011532363.1
	XM_011534063.2	17	8083	XP_011532365.1
	XM_011534064.2	17	8245	XP_011532366.1
	XM_011534065.2	16	7955	XP_011532367.1
	XM_011534066.2	15	8758	XP_011532368.1
	XM_017007118.1	16	8224	XP_016862607.1
	XM_017007119.1	16	7884	XP_016862608.1
	XM_017007120.1	14	7892	XP_016862609.1
	AI986459.1	1	379
	AK091226.1	1	3355

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759130	Chr.3:14869763 - 15121196 on Build GRCh38	Gain	NR2C2 FGD5 RBSN FGD5-AS1 MRPS25
nsv834620	Chr.3:14912162 - 15093316 on Build GRCh38	Gain	NR2C2 FGD5 RBSN FGD5-AS1 MRPS25

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

ribosomal protein, C4 zinc finger nuclear receptor

Gene Ontology Categories:

Process(es)

mitochondrial translational elongation
mitochondrial translational termination
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
spermatogenesis
nervous system development
cerebellum development
cell differentiation
p38MAPK cascade
positive regulation of embryonic development
steroid hormone mediated signaling pathway
positive regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of behavior
meiotic cell cycle
mitophagy in response to mitochondrial depolarization

Function(s)

structural constituent of ribosome
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
receptor activity
protein binding
zinc ion binding
sequence-specific DNA binding
protein heterodimerization activity