Hs02896685_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57516716 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1	4	940	NP_001181982.1
	NM_001195054.1	4	887	NP_001181983.1
	NM_001195055.1	4	864	NP_001181984.1
	NM_001195056.1	3	1050	NP_001181985.1
	NM_001195057.1	4	769	NP_001181986.1
	NM_004083.5	4	783	NP_004074.2
	AI658803.1	1	145
	AV729744.1
	AY461580.1	4	942
	BC003637.2	4	784	AAH03637.1
	BM464290.1	4	773
	S40706.1	4	774	AAB22646.1

Target Gene Details

• Entrez Gene ID: 4141
• Gene Name: methionyl-tRNA synthetase
• Gene Aliases: CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70
• Location: Chr.12:57487953-57516655 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 21

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MARS	NM_004990.3			NP_004981.2
	XM_006719398.3			XP_006719461.1
	AK122956.1
	BC002384.2			AAH02384.1
	BC006328.2			AAH06328.1
	BC011639.2			AAH11639.1
	BC011849.2			AAH11849.1
	BC015011.1			AAH15011.1
	D84224.1			BAA95668.1
	Z49216.1			CAA89153.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428283	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	MBD6 KIF5A GLI1 INHBE DDIT3 MARS PIP4K2C DCTN2 MIR6758 ARHGAP9 DTX3 INHBC MIR616
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	ARHGEF25 MBD6 KIF5A GLI1 DDIT3 MARS PIP4K2C DCTN2 MIR6758 ARHGAP9 DTX3 MIR616 LOC101927583
nsv469411	Chr.12:57450266 - 57527405 on Build GRCh38	Loss	MBD6 GLI1 INHBE MIR6758 ARHGAP9 DDIT3 INHBC MARS MIR616
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	SNORA105C COQ10A KIF5A INHBE TIMELESS NEMP1 DCTN2 STAT6 SNORD59A ZBTB39 ATP5B RDH16 BAZ2A HBCBP INHBC MIR616 LOC101927583 B4GALNT1 DDIT3 R3HDM2 APOF PIP4K2C SLC26A10 NACA ANKRD52 MYO1A SLC39A5 RNF41 HSD17B6 TAC3 MIR6758 SDR9C7 LRP1-AS NXPH4 SNORD59B GLS2 PTGES3 ARHGEF25 MBD6 GLI1 PAN2 SHMT2 MARS MIR1228 SPRYD4 NABP2 NDUFA4L2 DTX3 IL23A OS9 CS LRP1 CNPY2 STAC3 PRIM1 STAT2 RBMS2 ARHGAP9 NAB2 MIP GPR182

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

aminoacyl-tRNA synthetase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity
tRNA aminoacylation for protein translation
methionyl-tRNA aminoacylation

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity
tRNA binding
methionine-tRNA ligase activity
ATP binding