Hs02938812_cn

• Gene Symbol: ARPC4
• Assay Reference Genome Location: Chr.3:9792975 on build GRCh38
• Cytoband: 3p25.3

Target Gene Details

• Entrez Gene ID: 10093
• Gene Name: actin related protein 2/3 complex subunit 4
• Gene Aliases: ARC20, P20-ARC
• Location: Chr.3:9792495-9807105 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARPC4	NM_001024959.2			NP_001020130.1
	NM_001024960.2			NP_001020131.1
	NM_005718.4	1	428	NP_005709.1
	AW408422.1
	BG938423.1
	BI768875.1
	BI910730.1	1	428
	BQ688329.1
	DA226584.1
	DA909066.1	1	406
	DB060690.1

Target Gene Details

• Entrez Gene ID: 100526693
• Gene Name: ARPC4-TTLL3 readthrough
• Gene Aliases: -
• Location: Chr.3:9792548-9836356 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARPC4-TTLL3	NM_001198793.1	1	428	NP_001185722.1
	AK024110.1	1	418	BAB14828.1

Target Gene Details

• Entrez Gene ID: 10474
• Gene Name: transcriptional adaptor 3
• Gene Aliases: ADA3, NGG1, STAF54, TADA3L, hADA3
• Location: Chr.3:9779964-9793011 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TADA3	NM_001278270.1			NP_001265199.1
	NM_006354.3			NP_006345.1
	NM_133480.2			NP_597814.1
	NR_103488.1
	AK292264.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1010768	Chr.3:9502870 - 9873902 on Build GRCh38	Gain	OGG1 TTLL3 LOC107986062 LHFPL4 RPUSD3 CAMK1 ARPC4 MTMR14 CIDEC BRPF1 CPNE9 ARPC4-TTLL3 TADA3
nsv834615	Chr.3:9791053 - 9971639 on Build GRCh38	Loss	IL17RC EMC3 TTLL3 LOC107986062 RPUSD3 CRELD1 PRRT3-AS1 JAGN1 ARPC4 IL17RE CIDEC PRRT3 ARPC4-TTLL3 TADA3

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

actin or actin-binding cytoskeletal protein, cytoskeletal protein, chromatin/chromatin-binding, or -regulatory protein, histone modifying enzyme

Gene Ontology Categories:

Process(es)

actin filament polymerization
Arp2/3 complex-mediated actin nucleation
Fc-gamma receptor signaling pathway involved in phagocytosis
actin nucleation
ephrin receptor signaling pathway
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mitotic nuclear division
positive regulation of gene expression
intracellular estrogen receptor signaling pathway
regulation of histone deacetylation
regulation of protein stability
histone H3 acetylation
positive regulation of transcription, DNA-templated
regulation of tubulin deacetylation

Function(s)

structural constituent of cytoskeleton
protein binding
enzyme binding
protein binding, bridging
actin filament binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
histone acetyltransferase activity
ligand-dependent nuclear receptor binding
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity