Hs03441167_cn

• Gene Symbol: CFLAR
• Assay Reference Genome Location: Chr.2:201151252 on build GRCh38
• Cytoband: 2q33.1

Target Gene Details

• Entrez Gene ID: 8837
• Gene Name: CASP8 and FADD like apoptosis regulator
• Gene Aliases: CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
• Location: Chr.2:201116015-201172688 on Build GRCh38
• Assay Gene Location: Within Intron 14

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CFLAR	NM_001127183.2			NP_001120655.1
	NM_001202515.1			NP_001189444.1
	NM_001202516.1			NP_001189445.1
	NM_001202517.1			NP_001189446.1
	NM_001202518.1			NP_001189447.1
	NM_001202519.1			NP_001189448.1
	NM_001308042.1			NP_001294971.1
	NM_003879.5			NP_003870.4
	XM_017005189.1			XP_016860678.1
	XM_017005190.1			XP_016860679.1
	XM_017005191.1			XP_016860680.1
	XM_017005192.1			XP_016860681.1
	XM_017005193.1			XP_016860682.1
	XM_017005194.1			XP_016860683.1
	XM_017005195.1			XP_016860684.1
	XM_017005196.1			XP_016860685.1
	AF005774.1			AAC15825.1
	AF009616.1			AAB70909.1
	AF009617.1			AAB70910.1
	AF009618.1			AAB70911.1
	AF009619.1			AAB70912.1
	AF010127.1			AAB64110.1
	AF015450.1			AAC16439.1
	AF015451.1			AAC16440.1
	AF015452.1			AAC16441.1
	AF041458.1			AAB99790.1
	AF041459.1			AAB99791.1
	AF041460.1			AAB99792.1
	AF041461.1			AAB99793.1
	AF041462.1			AAB99794.1
	AK289913.1
	AK296036.1
	AK304585.1
	AK308767.1
	AK315208.1
	AK315924.1
	BC001602.1			AAH01602.1
	BT006751.1			AAP35397.1
	U85059.1			AAB82648.1
	U97074.1			AAC51622.1
	Y14039.1			CAA74366.1

Target Gene Details

• Entrez Gene ID: 65072
• Gene Name: CFLAR antisense RNA 1
• Gene Aliases: ALS2CR10
• Location: Chr.2:201140289-201157792 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CFLAR-AS1	NR_040030.1
	AB053312.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3593972	Chr.2:201143394 - 201156199 on Build GRCh38	Loss	CFLAR CFLAR-AS1
nsv584160	Chr.2:201039216 - 201298760 on Build GRCh38	Loss	ALS2CR12 CFLAR CASP8 CFLAR-AS1 FAM126B RPL17P10 CASP10 NDUFB3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

proteolysis
apoptotic process
skeletal muscle tissue development
skeletal muscle atrophy
regulation of skeletal muscle satellite cell proliferation
skeletal myofibril assembly
viral process
negative regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
regulation of necroptotic process
execution phase of apoptosis
negative regulation of myoblast fusion
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

protease binding
death receptor binding
protein binding
enzyme activator activity
protein complex binding
cysteine-type endopeptidase activity involved in execution phase of apoptosis